Browsing University of Galway Theses by Subject "DNA Damage Response"
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Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
(2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Genetic analysis of ATR, a central regulator of genome stability.
(2016-05-11)To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ...