Browsing University of Galway Theses by Author "College of Science, NUI Galway"
Now showing items 1-9 of 9
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Aspects of modeling and application of survival-type data
Fallah, Lida (NUI Galway, 2018-02)Survival analysis is collection of methods for analyzing data where the outcome of interest is the time to an event and some of the observations are censored. Survival data can arise naturally from studies on, machines' ... -
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
Gurry, Michael (2016-07-08)Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ... -
Design, synthesis and catalytic activity of novel oxazoline based ligands
Mc Cleary, Nadine (2015-08-14)This thesis can be viewed as two separate studies. Firstly, the design, synthesis and catalytic activity of novel 2-pyridyl mono(oxazoline). A family of mono(oxazoline) ligands were developed in which the 5-poition is ... -
Identification of novel factors that promote trinucleotide repeat instability
Concannon, Claire (2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
The lysine acetyltransferase MOF: its interactome, role in breast cancer, and characterisation of a novel isoform
Lane, Karen (2017-11-24)Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac), though it has also been shown to acetylate several ... -
Pathogen genomics of methicillin resistant staphylococcus aureus and leishmania
Coughlan, Simone (2017-02-15)Infectious diseases caused by the single-celled eukaryotic parasite Leishmania and the methicillin-resistant Staphylococcus aureus (MRSA) bacterium are major public health problems in many countries. In this thesis, I use ... -
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
Luessing, Janna (2017-07-05)The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ... -
Synthesis and Application of Novel Peptidic and Oxazoline Based Ligands for Asymmetric Catalysis
Geoghegan, Paul (2012-09-28)This thesis describes the synthesis and application of four novel chiral ligand classes. These were all hydroxyamide or oxazoline ligands with an L-pyroglutamic acid derived terminus. These ligands ... -
Thinning instabilities in biological and electroactive membranes
Greaney, Paul (NUI Galway, 2018-10-31)This thesis addresses several problems in the mathematical modelling of biological and electroactive membranes. We begin with a review of the necessary scientific background of biological and electroactive membranes. ...