Browsing University of Galway Theses by Subject "Chromatin"
Now showing items 1-6 of 6
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Contribution of non-histone proteins to chromatin structure and stability
(2015-10-30)Histones are responsible for packaging the genomes of almost all eukaryotes into fundamental repeating nucleosome units. The packaging must facilitate compaction into the cell nucleus but also enable dynamic access to the ... -
An epigenomics approach to characterize alterations in disease
(NUI Galway, 2023-01-13)Epigenetics is the term that describes all the mechanisms that regulate the genomic activities such as transcription, DNA repair, DNA replication, transposon duplication. There is a great variety of epigenetic mechanisms ... -
Functional Analysis of Vertebrate Msl2
(2014-02-12)hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ... -
Functional effects of inter-genome interactions on seed development in Arabidopsis thaliana
(NUI Galway, 2022-01-14)Plant seed size determination is of high economic interest for modern food production worldwide as many crops are mainly consumed in the form of seeds, such as rice, wheat or corn. Parental conflict and genomic imprinting ... -
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
(2017-02-15)Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ... -
Site-directed mapping of nucleosome structure and dynamics in vitro
(2013-03-04)The nucleosome core particle is the most basic unit of chromatin packaging. It is composed of an octamer of two each of the histone proteins H2A, H2B, H3 and H4 wrapped in ~147 bp of DNA. Nucleosome positioning and sliding ...