Browsing University of Galway Theses by Subject "Cell biology"
Now showing items 1-2 of 2
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Application of CRISPR/Cas9 gene editing to target Neuronal Interleukin-16 a novel protein involved in osteoarthritis progression
(NUI Galway, 2022-09-07)Osteoarthritis (OA) is a debilitating joint disease affecting an increasing proportion of the elderly population worldwide annually. Current treatments for the disease are symptomatic with management of pain and side effects ... -
A refined model of nucleolar formation derived from the analysis of UBF variants and the hierarchical silencing of human nucleolar organizer regions
(NUI Galway, 2017-03-23)The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed nucleolar organizer regions (NORs). As the site of ribosome biogenesis, nucleolar function is intrinsically linked to ...