Browsing University of Galway Theses by Subject "Carbohydrate"
Now showing items 1-4 of 4
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The anomerisation of glycosidic linkages
(2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ... -
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ... -
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and ...