Browsing University of Galway Theses by Subject "CENP-A"
Now showing items 1-4 of 4
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Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Centromere function in asymmetrically dividing Drosophila germline stem cells
(NUI Galway, 2023-03-28)Germline stem cells (GSCs) undergo asymmetric cell division (ACD) to give rise to one stem cell residing in the niche and one differentiating daughter cell. The daughter cell subsequently divides through mitosis and meiosis ... -
Epigenetic regulation of germline stem cell fate by Centromere Protein C
(NUI Galway, 2021-01-21)Germline stem cells (GSCs) divide asymmetrically to produce one new daughter stem cell and one daughter cell that will subsequently undergo meiosis and differentiate to generate the mature gamete. The ‘silent sister ... -
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
(2017-02-15)Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ...