Browsing University of Galway Theses by Subject "Biomedical engineering"
Now showing items 1-20 of 56
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Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
(NUI Galway, 2018-09-28)Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ... -
Bioinspired micropatterned adhesive surfaces for medical applications: a numerical investigation of fibrillar adhesives and swellable microneedle arrays
(NUI Galway, 2024-03-21)Traditional sutures and tissue adhesives can cause adverse effects, inflicting additional damage to the tissue, resulting in toxic chemical residues, and increasing the risk of infection. Bioinspired adhesives have ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
(NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
Biomimetic nano-biomaterials for bone repair and regeneration
(2017-02-24)Currently, over 1.7 billion people suffer from a musculoskeletal disorder; over 200 million operations take place annually; and in excess of 1 million new clinical cases are reported per year. Further, the annual healthcare ... -
Biophysical and biochemical microenvironmental cues for tenogenic phenotype maintenance, differentiation and trans-differentiation in vitro
(NUI Galway, 2019-07-19)Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years. ... -
Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
(NUI Galway, 2018-11-27)The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ... -
Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration
(2015-11-30)Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and ... -
A computational and experimental investigation of the biomechanics of nickel-titanium stents for femoropopliteal applications
(NUI Galway, 2023-06-15)Self-expanding nickel-titanium stents are the current gold-standard in treating peripheral artery disease in the femoropopliteal artery. Despite this, failure rates in the femoropopliteal artery are much higher than ... -
A computational and experimental investigation of the dissection of arterial tissue
(NUI Galway, 2020-11-19)The overall objective of this thesis is to provide a new understanding of the mechanisms underlying arterial fracture, and to extend this understanding to the initiation and propagation of aortic dissection using a combination ... -
A computational and experimental investigation of the in-vivo biomechanics of the human aorta
(NUI Galway, 2020-07-06)The overall objective of this thesis is to provide a new understanding of the degree of biomechanical heterogeneity that exists along the human aorta, against the backdrop of clinical literature reporting that patient ... -
A computational and experimental investigation of tracheobronchial stent performance
(2017-05-25)Tracheobronchial stents are used to relieve blockages in the respiratory tree, typically caused by lung cancer. However, multiple complications can be associated with stents for this indication. In order to be able to ... -
Computational modelling of the coupled electro-mechanical behaviour of neurons
(NUI Galway, 2019-01-22)Recent experimental evidence has uncovered complex biophysical phenomena accompanying the electrical activity of nervous cells. Now emerging theories refer to the electric pulse, i.e. the Action Potential (AP), as an ... -
Computational modelling of the degradation of poly-L-lactide for a bioresorbable polymeric stent
(NUI Galway, 2020-05-08)The interest in biodegradable polymers for the design of bioresorbable stents, temporary vascular scaffolds designed to restore patency to obstructed vessels, has witnessed a dramatic growth over the last ten to fifteen ... -
Design and evaluation of an automated algorithm for cardiac risk stratification
(2013-12-20)In the United States, sudden cardiac death (SCD) claims approximately 450,000 lives each year, more lives than stroke, lung and breast cancer and AIDS combined. In the United Kingdom and Ireland, the combined figure is ... -
Detecting seen/unseen objects with reducing response time for multimedia event processing
(NUI Galway, 2021-09-01)The enormous growth of multimedia content in the domain of the Internet of Things (IoT) leads to the challenge of processing multimedia streams in real-time. Thus, the Internet of Multimedia Things (IoMT) is an emerging ... -
Development and characterisation of compressed, macro-porous and collagen-coated poly-ε-caprolactone electrospun meshes
(NUI Galway, 2019-02-25)Electrospun scaffolds are utilised in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialisation. However, the very dense architecture and the low ... -
Development of a gene-eluting stent for the treatment of in-stent restenosis
(2016-05-12)In-stent restenosis (ISR) results from stent-induced arterial injury, characterized by a complex cascade of cellular and biochemical events. The removal of endothelium during an angioplasty procedure causes the underlying ... -
Development of a mixed glial in vitro robust platform for therapeutic applications in spinal cord injury
(NUI Galway, 2021-06-30)Spinal cord injury (SCI) is a catastrophic event, and current strategies for SCI pose several limitations. One of the critical hallmarks of SCI is inflammation, which is due to the activation of microglia and astrocytes. ... -
Development of anisotropic polymeric substrates for tendon tissue engineering
(2015-09-11)Tendon injuries and degenerative conditions constitute an unmet clinical need with pharmacological strategies and tissue grafts failing to recapitulate native tendon function. Advancements in bioengineering have enabled ...