Browsing University of Galway Theses by Author "Aldabbagh, Fawaz"
Now showing items 1-12 of 12
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Barton esters for initiator-free radical cyclisation with heteroaromatic substitution and anti-cancer evaluation of benzo[e][1,2,4]triazin-7-ones
Coyle, Robert (2014-07-03)Chapter 1 provides a general introduction to Chapters 2-5. Homolytic aromatic substitution routes to alicyclic ring-fused azoles and diazoles is reviewed. A review of recent literature using the COMPARE program of the ... -
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
Gurry, Michael (2016-07-08)Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ... -
Chain transfer to solvent in the radical polymerization of acrylamide monomers, controlled/living radical polymerizations, including in supercritical carbon dioxide and preparation of carbon dioxide responsive micelles
Magee, Christopher (2014-12-11)Chapter 1 provides a general introduction to radical polymerization, including chain transfer, and controlled/living radical polymerization. A review of the literature since 2009 on heterogeneous controlled/living radical ... -
First Synthesis of an Aziridinyl Fused Pyrrolo[1,2-a]benzimidazole and Cytotoxicity Evaluation of Various Imidazobenzimidazolequinones Towards Human Normal and Cancer Cell Lines
Bonham, Sarah (2011-07-13)Chapter 1 provides a review of aziridine containing anti-tumour agents and some key syntheses of the aziridinomitosene skeleton. A novel protocol for aziridine ring fusion is described leading to the preparation of the ... -
Heterocyclic chemistry: Controlled unmasking of nitric oxide and nitroxides
Kielty, Patrick (NUI Galway, 2019-11-29)Nitric oxide (NO) is a gaseous free radical with medicinally significant properties. The NO-releasing prodrug, isosorbide-5-mononitrate (Is5N), is long established for the treatment of angina pectoris. Nitroxides are organic ... -
Hydrogen peroxide and hydrohalic acid mediated synthesis of halogenated benzimidazolequinones and anti-cancer evaluation of benzotriazinones
Sweeney, Martin (NUI Galway, 2019-11-29)Chapter 1 provides a literature review of metal and metal-free oxidative annulations employed to access ring-fused benzimidazoles while highlighting their significance and application towards anti-tumour benzimidazolequinones. ... -
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
Alzahrani, Abdullah (NUI Galway, 2018-10-15)Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ... -
The Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization of cyanoacrylates
Duffy, Cormac (2018-02-02)Alkyl 2-cyanoacrylates (CAs) are primarily used as instant adhesives, including those sold under the Loctite brand. The adhesive action can be inhibited with acid stabilisers allowing radical polymerization to be employed. ... -
Small-molecule-based crosslinking and bioconjugation of biomolecules
Keane, Lee-Ann (NUI Galway, 2020-01-10)Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging area of chemical biology. The superior nucleophilicity of cysteine presents it as a uniquely reactive bioconjugation handle. ... -
Synthesis and Anti-Cancer Activity of Novel Imidazo[5,4-f]benzimidazolequinones
Fagan, Vincent (2011-08-24)Chapter 1; A literature review of chemotherapeutic agents, bioreductive prodrugs and polycyclic diazoles, along with the aims and objects of the thesis is presented. Chapter 2; A review of 'oxidative' homolytic aromatic ... -
The use of Acetic Anhydride in Annulations onto Benzimidazoles to give Novel Reducible p-Dione Adducts
Joyce, Eamonn (2012-06-13)Chapter 1: Introduction to the reactive intermediates used in this thesis, namely acyl radicals and N-heterocyclic carbenes (NHC) is presented, along with an assessment of the anti-cancer activity of literature bioreductive ... -
The use of reversible addition-fragmentation chain transfer (RAFT) polymerization, supercritical carbon dioxide and new hetero-containing monomers in polymer chemistry
Hawkins, Gerard (2017-08-28)Chapter 1 is a general introduction with a description of conventional radical polymerization and reversible deactivation radical polymerizations for controlled/living techniques. In particular, the use of Reversible ...