Browsing University of Galway Theses by Subject "cancer"
Now showing items 1-4 of 4
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A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
The impact of cognitive dysfunction on the occupational performance of cancer survivors post chemotherapy
(NUI Galway, 2024-03-13)Background: Cancer rates are increasing globally. Survivorship is also rising due to advancements in early detection and treatment. Chemotherapy is a common anti-cancer treatment with adverse effects reported due to its ... -
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ... -
Toward dual-action platinum(IV) complexes with bioactive ligands as potent anticancer agents
(NUI Galway, 2020-02-20)Platinum agents (cisplatin, carboplatin and oxaliplatin) have a crucial role in the treatment of many cancers for several decades. However, they have severe side effects and a high number of patients have intrinsic or ...