Browsing University of Galway Theses by Subject "Prostate cancer"
Now showing items 1-10 of 10
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Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ... -
Dashboards for supporting cancer care in value-based healthcare context – Information needs, design principles and acceptance
(NUI Galway, 2021-09-19)Improving the value of care is central to the value-based healthcare model. This model emphasises the active role of patients in decision making and providing them with the information they require during the different ... -
Development of a psychometric measure of physical post traumatic growth in prostate cancer and evaluation of its role in predicting psychological adjustment
(2015-01-30)Post traumatic growth (PTG) can be defined as positive change following a traumatic event (Tedeschi & Calhoun, 1995). The current conceptualisation of PTG encompasses five main dimensions: perceived changes in self; ... -
An epigenomics approach to characterize alterations in disease
(NUI Galway, 2023-01-13)Epigenetics is the term that describes all the mechanisms that regulate the genomic activities such as transcription, DNA repair, DNA replication, transposon duplication. There is a great variety of epigenetic mechanisms ... -
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
(2016-11-30)Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ... -
Expression Profiling of circulating micro-RNAs in Prostate Cancer
(2013-08-06)Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs in the blood of ... -
Human endogenous retrovirus K (HERV-K) in prostate cancer
(2016-08-08)Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ... -
Preclinical assessment of the novel compound EL102 in prostate cancer
(2015-03-31)Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ... -
Ultrasound imaging in radiotherapy and dosimetric quantification with Monte Carlo techniques
(2017-12-21)This thesis considered the use of ultrasound-based image guidance systems, employed to account for internal motion of the prostate gland during radiotherapy. A clinical evaluation of the Clarity soft tissue visualisation ...