Browsing University of Galway Theses by Subject "Hypoxia"
Now showing items 1-5 of 5
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Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
(2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ... -
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(2016-04-22)The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ... -
Preclinical assessment of the novel compound EL102 in prostate cancer
(2015-03-31)Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ...