Browsing University of Galway Theses by Author "Zeugolis, Dimitrios"
Now showing items 1-15 of 15
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Biomimetic nano-biomaterials for bone repair and regeneration
Azeem, Ayesha (2017-02-24)Currently, over 1.7 billion people suffer from a musculoskeletal disorder; over 200 million operations take place annually; and in excess of 1 million new clinical cases are reported per year. Further, the annual healthcare ... -
Biophysical and biochemical microenvironmental cues for tenogenic phenotype maintenance, differentiation and trans-differentiation in vitro
Ryan, Christina (NUI Galway, 2019-07-19)Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years. ... -
Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
Gaspar, Diana (NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
Kumar, Pramod (2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Development and characterisation of compressed, macro-porous and collagen-coated poly-ε-caprolactone electrospun meshes
Fuller, Kieran P. (NUI Galway, 2019-02-25)Electrospun scaffolds are utilised in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialisation. However, the very dense architecture and the low ... -
Development of anisotropic polymeric substrates for tendon tissue engineering
English, Andrew (2015-09-11)Tendon injuries and degenerative conditions constitute an unmet clinical need with pharmacological strategies and tissue grafts failing to recapitulate native tendon function. Advancements in bioengineering have enabled ... -
In the quest of the optimal collagen type II source for articular cartilage engineering
Wu, Zhuning (NUI Galway, 2021-08-26)Articular cartilage is a specialised connective tissue of joints, which lacks blood vessels, lymphatics and nerves. The limited capability of articular cartilage to self-repair renders its regeneration a formidable challenge. ... -
The influence of collagen isolation, cross-linking and sterilisation on macrophage response
Delgado, Luis Maria (2018-03-07)Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ... -
The influence of collagen type I source and cross-linking on cell function and phenotype maintenance
Sorushanova, Anna (NUI Galway, 2023-09-13)Collagen is a complex supramolecular structure that occurs in highly diverse morphologies across different tissues, lending them a range of physical and biological functions. Collagens have a long history in both ... -
Macromolecular crowding for chondrogenic phenotype maintenance and stem cell differentiation
Graceffa, Valeria (NUI Galway, 2019-01-31)Chondrocyte-based tissue engineering therapies require in vitro cell expansion, which is associated with loss of phenotype, decrease in synthesis of collagen type II and increase in synthesis of collagen type I. Another ... -
Macromolecular crowding meets tissue engineering by self-assembly
Satyam, Abhigyan (2015-01-29)Introduction: Advancements in molecular and cell biology have led to the development of tissue engineering by self-assembly. The driving hypothesis of this concept is that replacement, repair and restoration of lost tissue ... -
Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional tissue moduli
De Pieri, Andrea (NUI Galway, 2020-11-04)Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, traditional cell-assembled tissue ... -
Novel approaches to the understanding and treatment of postoperative pain
Power, Emer (NUI Galway, 2019-12-06)Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ... -
Replicating and modulating skin fibrosis in vitro: Multi-compartment collagen devices as dual drug delivery vehicles
Coentro, João (NUI Galway, 2022-01-10)Complex pathologies, such as fibrosis, are often not the result of a singular event, but rather the consequence of multiple disruptions in the normal balance between intricately connected organs, tissues and signalling ... -
Three-layer collagen-based composite scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair
Pugliese, Eugenia (NUI Galway, 2023-09-28)The enthesis is a specialised interfacial tissue responsible to minimise stress concentrations between tendon and bone. Fibrocartilaginous entheses are composed of four distinct areas, namely tendon, unmineralised ...