Browsing University of Galway Theses by Author "O'Brien, Timothy"
Now showing items 1-12 of 12
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Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
Chao, Joshua (NUI Galway, 2020-05-08)Stromal cells have long been studied for their putative role in maintaining tissue homeostasis, driving tissue remodeling processes during injury, and modulating inflammation by synergizing with immune cells. Studying ... -
An analysis of the health risks associated with international travel
Flaherty, Gerard (2015-01-28)This thesis, submitted for the award of a doctoral degree in Medicine, represents an attempt to collate all of my original research projects in travel medicine completed at NUI Galway. Chapter 1 presents four projects ... -
Anti-Inflammatory Gene Therapy for the Promotion of Implanted Stem Cell Survival in Infarcted Myocardium
Holladay, Carolyn (2011-04-13)Cardiovascular disease is the leading cause of death in the developed world and is responsible for approximately 36% of Irish mortality. Myocardial infarction (MI), which is literally the death of cardiac tissue due to ... -
Axonal Regeneration Supported by Oligo[poly(ethylene glycol)fumarate] Cell-Loaded Hydrogel Scaffolds in the Transected Rat Spinal Cord
Madigan, Nicolas Niall (2012-04-16)Spinal cord injury results in complete tissue destruction and irreversible loss of neurologic function below the level of the lesion in 40% of patients in Ireland. Tissue engineering using polymer scaffolds offers potential ... -
Biological characterization of a human mesenchymal stromal cell product
Creane, Michael (2016-07-21)The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
Thomas, Dilip (2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Development of next generation MSC therapeutics for critical limb ischaemia
Sanz Nogués, Clara (2015-02-19)Cell therapy with mesenchymal stem cells (MSCs) is being explored as a treatment for many ischaemic conditions of unmet medical need, such as critical limb ischaemia. MSC transplantation in humans has occurred in both ... -
Examining the role of a novel stromal cell protein CD362/Syndecan-2 in the breast tumour microenvironment.
Loftus, Paul Gerard (NUI Galway, 2019-09-04)Tumour-associated stromal cells play a key role in initiating and sustaining tumour growth, metastasis, immune control and chemo-resistance. Thus, identifying stromal proteins that contribute to carcinogenesis may open new ... -
Genetically modified mesenchymal stem cells overexpressing CCR2 for cell therapy in critical limb ischemia
Thirumaran, Arun (2017-09-21)Critical Limb Ischemia (CLI) is an advanced stage of Peripheral Arterial Disease (PAD) and a global health problem. Patients with CLI may present with rest pain, gangrene and/or ulceration of the lower limb. Effective ... -
Human stem cell modelling for heart disease of long QT syndrome
Ge, Ning (NUI Galway, 2022-04-29)Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated ... -
Novel Cell-Based Therapies for the Treatment of Diabetic Ulceration
O'Loughlin, Aonghus (2012-02-28)The focus of this research is on developing novel cell based therapies for the treatment of non-healing diabetic foot ulceration. The thesis begins with a concise review of the diabetic foot ulcers. The burden associated ... -
Therapeutic applications of endothelial progenitor cells for diabetic ulcer healing
Kealy, John Brian (2016-10-16)Diabetic ulcer healing is a major problem in health care. Impaired circulation has long been associated with diabetes resulting in an increased risk of foot ulceration and making an increase in blood flow an excellent ...