Browsing University of Galway Theses by Author "Lowndes, Noel F."
Now showing items 1-5 of 5
-
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
Baldascini, Marta (NUI Galway, 2019-12-16)The integrity of our genome is very important therefore, our cells have developed efficient DNA repair mechanisms to control this integrity and avoid mutations. Although the DNA double strand break response pathway is ... -
Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
Calvo Asensio, Irene (2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Genetic analysis of ATR, a central regulator of genome stability.
Llorens-Agost, Marta (2016-05-11)To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ... -
KIF18B, a nuclear kinesin, is involved in DNA damage response
Sakhteh, Maryam (NUI Galway, 2021-03-08)DNA damage from both exogenous and endogenous sources occurs continuously in all cells. A multitude of DNA repair mechanisms have evolved to maintain genome stability. The 53BP1 tumour suppressor has been identified as a ... -
The microprocessing factor DGCR8 interacts with ATM and functions independently of its partner DROSHA in the DDR
Murphy, Stephen (NUI Galway, 2020-01-23)The eukaryotic cell has evolved a complex suite of mechanisms called the DNA damage response (DDR), that acts by sensing DNA damage and reacting appropriately to maintain genomic integrity. The PIK kinase ATM is a key ...