Browsing University of Galway Theses by Title
Now showing items 1449-1468 of 2276
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Modulation of inflammatory pain in intervertebral disc degeneration: A therapeutic biomaterials approach
(2017-10-05)Discogenic low back pain (LBP) is a very common health problem that imposes a socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the causative factors of LBP. It is mediated by an ... -
Molecular Beacons for Tissue Engineering Applications
(2012-09-28)A complete spatiotemporal profile of the mechanisms involved in the synthesis, processing, and transport of RNA will improve our understanding of cell function and behaviour under various biological cues, which could ... -
Molecular characterisation of norovirus contamination in wastewater and oysters
(2014-05-16)Bivalve molluscan shellfish (BMS), such as oysters, when grown in waters impacted by human wastewater may bioaccumulate human enteric viruses such as Norovirus (NoV). NoV is the leading agent of foodborne viral gastroenteritis ... -
Molecular Characterisation of the HIV-1 Epidemic in Karonga District, Malawi, with Particular Emphasis on Long-Term Survivors
(2012-06-14)HIV-1 has been studied in the Karonga District in northern Malawi for almost 30 years (1982-2010). Within Karonga a cohort of subtype C long-term survivors were identified who have been followed for over 20 years with ... -
The molecular characterization of ER stress-induced autophagy and cell death
(2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
Molecular determinants of CTG.CAG repeat expansions in Huntington's disease
(2017-10)CTG•CAG repeat expansions are the underlying genetic cause for at least 12 inherited neurological disorders, including Huntington’s disease (HD) and myotonic dystrophy type I (DM1). Trinucleotide repeats (TNRs) are very ... -
Molecular ecology of the honey bee Apis mellifera L. in Ireland
(NUI Galway, 2021-12-10)The honey bee sub-species native to Ireland is Apis mellifera mellifera, referred to locally as the Black bee. It is the same sub-species that has undergone widespread extinction across the rest of its native range in ... -
Molecular evolution of imprinted, orphan and De novo genes in plant genomes
(2016-02-23)A range of different genetic processes can facilitate species-specific adaptations. These include orphan genes and genes subject to genomic imprinting. All organisms are known to contain unique genes that have no recognizable ... -
A molecular genetic investigation into stress sensing in the food-borne pathogen Listeria Monocytogenes: roles for RsbR and its paralogues
(2016-11-30)The alternative sigma factor σB is conserved across several Gram-positive bacteria species as the major general stress response (GSR) regulator. For the food-borne pathogen Listeria monocytogenes, σB enables the bacterium ... -
Molecular genetic investigation towards functions of imprinted genes in reproduction and seed development in Arabidopsis thaliana
(2017-01-26)In flowering plants and placental mammals a subset of genes known as imprinted genes display full or partial suppression or activation to one of its alleles in a parent of origin dependent manner. During maternal and ... -
Molecular impact of Human Endogenous Retrovirus K (HERV-K) on breast cancer progression
(NUI Galway, 2021-07-28)Viruses have left their mark on the human genome over millions of years in the form of human endogenous retroviruses (HERVs). These retroelements inserted themselves into our germline, became inherited in a Mendelian ... -
Molecular investigation into the roles of Sigma B and the Stressosome in the response of Listeria monocytogenes to environmental stress
(NUI Galway, 2019-07-15)The alternative sigma factor, SigB, has been studied extensively in Listeria monocytogenes, Bacillus subtilis and Staphylococcus aureus, and is known to regulate the general stress response in these bacteria. The activation ... -
Molecular mechanisms and tumour heterogeneity in breast cancer
(2014-05-07)MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ... -
The molecular mechanisms governing the colonisation of intestinal epithelial cells by Vibrio parahaemolyticus
(2012-12-19)Vibrio parahaemolyticus is a food borne gastro-intestinal pathogen of major global importance. The organism induces severe inflammatory diarrhea in individuals who become infected due to the consumption of contaminated ... -
The Molecular Mechanisms of 5-Fluorouracil-Induced Apoptosis in Human Colorectal Cancer Cells and the Use of 5-FU as a Sensitising Agent to TRAIL
(2012-09-28)Colorectal cancer is the third most common cause of death worldwide and despite many advances in recent years resistance to apoptosis induced by chemotherapeutic drugs, such as 5-fluorouracil (5-FU), remains a serious ... -
Molecular microbial ecology of ammonia oxidation in coastal sediments
(2017-02-10)This thesis focuses on the processes of nitrification in three coastal bays, specifically, aerobic ammonia oxidation which is the rate limiting step of nitrification and is mediated by ammonia oxidising bacteria and/or ... -
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ... -
Molecular tools for the identification and localization of algal cell wall components
(2016-01-11)Cell wall glycan-directed monoclonal antibodies (mAbs) are sensitive tools for the detection of wall components in vitro (glycome profiling) and in situ (immunolocalization). Although extensively applied to land plant and ... -
Monitoring methods and bloom dynamic studies of the toxic dinoflagellate genus Alexandrium
(2014-06-03)Records of annual monitoring of the dinoflagellate genus Alexandrium in Cork Harbour, Ireland date back to the 1990's. Intense bloom densities in this area have caused major economical loss and impacted negatively on the ... -
Monolingual alignment of word senses and definitions in lexicographical resources
(NUI Galway, 2022-07-31)Dictionaries are fundamental resources for people to learn and document languages as well as for computers to process natural languages. A dictionary provides a fine-grained structure and description of the vocabulary of ...