Browsing University of Galway Theses by Title
Now showing items 1279-1298 of 2226
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Machine learning and high-performance computing: Infrastructure and algorithms for the genome-scale study of genetic and epigenetic regulatory mechanisms with applications in neuroscience
(2014-06-30)The advent of next-generation sequencing (NGS) has fundamentally changed modern genomics re-search. These sequencers generate terabytes of data and necessitate the use, not only of high-performance compute (HPC) clusters ... -
Machine learning applied to electrical impedance tomography for the improved management of nocturnal enuresis
(NUI Galway, 2021-06-04)Nocturnal Enuresis (or bedwetting) is a condition that commonly affects children but can continue into adulthood. The condition can have serious implications on the quality of a child’s life. The current first-line medical ... -
Machine learning for De Novo peptide identification
(NUI Galway, 2023-04-21)Proteomics involves the identification and analysis of proteins, therefore providing valuable insight into ecosystem functioning. In this methodology, protein sequences are typically identified using a bottom-up approach ... -
Machine translation of domain-specific expressions within ontologies and documents
(2017-08-08)Nowadays, most of the semantically structured data have labels stored only in English. Although the increasing number of ontologies offers an excellent opportunity to link this knowledge together, non-English users may ... -
Macro- and micro-scale modelling of material inhomogeneity for the premature failure of welded 9Cr steels in power plants
(NUI Galway, 2019-02-15)Chromium-molybdenum steel pipe (9Cr-1Mo steel) is an important high temperature construction material for welded steam piping networks in gas-fired power plants. A major global problem of such materials is the premature ... -
Macromolecular crowding alone or in combination with other in vitro microenvironment modulators to maintain tenogenic phenotype in vitro
(NUI Galway, 2020-07-15)Tendon injuries are very common among the different musculoskeletal disorders affecting millions of people annually. Given that current treatments have failed to restore injured tendons to the prior to injury state, ... -
Macromolecular crowding for chondrogenic phenotype maintenance and stem cell differentiation
(NUI Galway, 2019-01-31)Chondrocyte-based tissue engineering therapies require in vitro cell expansion, which is associated with loss of phenotype, decrease in synthesis of collagen type II and increase in synthesis of collagen type I. Another ... -
Macromolecular crowding meets tissue engineering by self-assembly
(2015-01-29)Introduction: Advancements in molecular and cell biology have led to the development of tissue engineering by self-assembly. The driving hypothesis of this concept is that replacement, repair and restoration of lost tissue ... -
Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional tissue moduli
(NUI Galway, 2020-11-04)Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, traditional cell-assembled tissue ... -
Magnetic and interpolation techniques in the identification and analysis of metal contaminants In urban soils
(NUI Galway, 2019-06-28)Soil pollution has been identified as the third most important threat to soil quality in Europe. There are an estimated ~2,000 potentially contaminated sites in Ireland alone. Metal contamination has been identified as one ... -
Magnetotelluric research of the Rathlin Basin
(NUI Galway, 2018-12-24)The IRETHERM Project was funded under SFI PI Grant 10/IN.1/I3022, with the aim of addressing uncertainties and gaps in the knowledge of potential geothermal resources within Ireland. This thesis presents geophysical ... -
Mainstreaming disability in development aid: A comparative analysis of the United States Agency for International Development, the Australian Agency for International Development and the Ministry for Foreign Affairs of Finland
(2014-05-15)Intergovernmental organisations such as the United Nations (UN) and the World Bank claim that the majority of the one billion persons with disabilities worldwide live in developing countries and are at high risk of poverty ... -
Maintenance of the spindle assembly checkpoint by PLK1 and CDC7 kinases and characterisation of cell lines carrying mutations in the genes coding for the CDC7 regulatory subunits
(2016-11-15)The Spindle Assembly Checkpoint (SAC) ensures that accurate chromosome segregation occurs, by preventing progression into anaphase until all kinetochore-microtubule attachments are stable and bi-polar. During a mitotic ... -
Making the most of multimedia learning: evaluating the impact of combined audiovisual translation tasks on the acquisition of L2 multiword expressions
(NUI Galway, 2019-09-16)The use of audiovisual material in the Italian L2 classes in the last decades has acquired an increasingly important role, especially since the communicative approach has identified spoken language as the main objective ... -
Making the new space created in the UN CRPD real: Ensuring the voice and meaningful participation of the disability movement in policy-making and national monitoring
(2014-12-16)The participation of persons with disabilities in policy and legislative processes and in monitoring the implementation of the UN Convention on the Rights of Persons with Disabilities (CRPD) is an international legal ... -
Man the Tamer: case studies in masculine ideology, power and the domestication of the wild in Ancient Greek social thought
(NUI Galway, 2021-01-04)Drawing on the strong tradition of structuralism in the Classics, this thesis argues that the binary opposition between wild and tame was fundamental to the Ancient Greek man's understanding of social power relations. It ... -
Management control in Spanish public hospitals: healthcare accreditation
(2017-04-03)This study examines the operation of a mandatory healthcare accreditation system to achieve a better understanding of how an externally imposed system operates as a management control tool. Adopting a qualitative research ... -
Management of chemotherapy-induced neutropenia in cancer patients
(NUI Galway, 2023-03-06)Chemotherapy is widely used as a successful treatment option for cancer patients, showing a higher success rate in hematological cancers than solid tumours. Chemotherapy-induced neutropenia (CIN), defined as “a reduction ... -
“Managing Pain by Tradition”: a constructivist grounded theory study exploring how patients live with and manage their pain
(NUI Galway, 2023-01-04)Living with persistent unresolved chronic pain is known to negatively impact on a person’s physical, psychological, and social well-being. Chronic pain associated with chronic leg wounds or ulcers can affect up to 65% of ... -
Mapping protein architecture in centromeres of Equus asinus
(2016-11-28)The centromere is a genetic locus present once per chromosome that specifies the site of kinetochore formation and is vital for chromosomal segregation. With the exception of Saccharomyces cerevisiae, whose ‘point’ ...