Browsing University of Galway Theses by Author "Pandit, Abhay"
Now showing items 21-28 of 28
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Molecular Beacons for Tissue Engineering Applications
Alexander, Jennifer (2012-09-28)A complete spatiotemporal profile of the mechanisms involved in the synthesis, processing, and transport of RNA will improve our understanding of cell function and behaviour under various biological cues, which could ... -
A multi-modal collagen nucleic acid delivery system for the modulation of inflammation and promotion of angiogenesis
Shane, Browne (2014-12-15)Tissue engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue engineered constructs, ... -
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
Chan, Jeffrey (NUI Galway, 2018-10-19)Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory results from using autografts and allografts for hernia repairs. More than fifty years later, polypropylene is still the most popular ... -
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
Jarrin, Sarah (NUI Galway, 2019-11-15)Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ... -
The role of glycosylation in intervertebral disc degeneration: Towards glyco-functionalised therapeutics
Joyce, Kieran (NUI Galway, 2021-09-24)Low back pain (LBP) is a common health issue that imposes a significant socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the major contributing causes of LBP. It is initiated by altered ... -
Strategies to Modify the Diatom Thalassiosira weissflogii for Use as a Biotemplate to Generate Hierarchical Polymeric Microcapsules
Lang, Yvonne Mary (2013-12-20)The aim of this research study was to generate a polymeric capsule with hierarchical architecture employing the diatom frustule as a sacrificial biotemplate. Both pennate and centric diatoms were isolated from Galway bay ... -
Synthesis of model compounds acting as Nitric Oxide (NO)-scavengers and the fabrication of NO-scavenging hydrogels targeting the treatment of triple-negative breast cancer
Abdo, Amir (NUI Galway, 2023-07-31)Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with an early recurrence within two to three years of first diagnosis. Moreover, the heterogeneity of the TNBC tissue creates ... -
Towards an optimal microenvironment for nucleus pulposus regeneration: a glycobiology approach
Collin, Estelle (2013-04-11)Neck and low back pain are the two highest causes of job-related disability in the UK and the USA. These pathologies are strongly related to intervertebral disc degeneration (IVD). Disc degeneration diseases (DDD) are ...