Browsing University of Galway Theses by Title
Now showing items 923-942 of 2275
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Generating and ranking candidate data models from background knowledge
(NUI Galway, 2021-01-04)Knowledge graphs have emerged as a core technology to publish, share, and integrate data on the Web. Contrary to traditional data storage solutions, such as relational databases, one of the core functionalities of Knowledge ... -
Generation of natural killer cell-mimic nanoparticles to target tumour cells
(NUI Galway, 2022-05-30)Natural killer (NK) cells are effector immune cells in the innate immune system. It is increasingly recognised that NK cells play a crucial role eliminating emerging tumour cells. Some tumour cells however can escape and ... -
Generation of recombinant anti-N-glycolylneuraminic acid (Neu5Gc) scFv and its applications for detection and quantitation of Neu5Gc
(2016-05-12)Sialic acids are a family of 9 carbon α-keto acid monosaccharides. Owing to their terminal position on glycans, sialic acids are involved in cell adhesion and recognition events, host pathogen interactions, immune regulation ... -
Generational understanding of social support, youth civic engagement and coping as aspects of resilience in socialist and post-socialist Slovenia (1980-2011)
(2015-09-30)This thesis explores the link between protective factors and youth coping as aspects of resilience within the context of social change. The most recent evidence from resilience research shows there is a significant link ... -
The genesis of the Europeanisation of the Northern Ireland peace process
(2018-01-17)The thesis examines the economic and political contributions of the European Union (EU) to the Northern Ireland peace process, tracing the genesis of EU involvement and analysing how it acted as an arena in which to ... -
Genesis of the Moly Brook molybdenum-copper deposit, Newfoundland, Canada: Geological and geochemical constraints on fluid evolution, links with adjacent tungsten mineralization, and the role of Late Devonian granitic intrusions
(NUI Galway, 2017-08-25)An integrated geological, structural and geochemical study of the Moly Brook Mo-Cu deposit, southern Newfoundland (Canada), is presented. The role of subordinate leucogranite as progenitor to the mineralizing components ... -
Genetic analysis of ATR, a central regulator of genome stability.
(2016-05-11)To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ... -
Genetic analysis of carotenoid accumulation in tropical maize inbred lines using molecular tools and field tests for accelerating the biofortification of maize with provitamin A
(2015-05-13)Improving the nutritional content of staple crops through breeding (biofortification) is promoted as cheap and sustainable approach for alleviating vitamin A and other micronutrient deficiencies across the world. Maize is ... -
Genetic and biotechnological development of the pennate marine diatom Phaeodactylum tricornutum for high-value bioproducts and carbon bio-mitigation.
(2014-04-25)Conflicting demands of food over fuel and the mushrooming need for feed and fibre are serious challenges for humankind at a time when we also need to address climate change challenges. Global demands for land based commodities ... -
Genetic basis for dosage sensitivity of seed size heterosis in Arabidopsis thaliana
(NUI Galway, 2021-09-08)Heterosis refers to the ability of the F1 offspring to display superior characteristics compared with their parents and despite being genetically studied since the early 1900s, many aspects of this phenomenon remain unclear. ... -
Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ... -
Genetic diversity, evolutionary history and epigenetic analysis of East African highland bananas
(2015-05-13)Genetic variation describes naturally occurring genetic differences among individuals of the same species and permits flexibility and survival of a population in the face of changing environmental circumstances, diseases ... -
Genetically modified mesenchymal stem cells overexpressing CCR2 for cell therapy in critical limb ischemia
(2017-09-21)Critical Limb Ischemia (CLI) is an advanced stage of Peripheral Arterial Disease (PAD) and a global health problem. Patients with CLI may present with rest pain, gangrene and/or ulceration of the lower limb. Effective ... -
Genome dosage and parent of origin effects in a ploidy series of Arabidopsis thaliana
(2013-11-11)Polyploidy, the presence of more than two sets of chromosomes in an organism, plays major roles in plant evolution, development and function. Understanding the effects of polyploidization at the phenotypic and molecular ... -
Genome dosage, genetic hybridity and crop improvement
(NUI Galway, 2020-03-02)Plant breeding is focussed on introducing novel traits in plants, as well as enhancing or repressing traits already present. A noble objective in agriculture is to produce more food per unit area with overall fewer resources. ... -
Genomic and transcriptomic investigations into the feed efficiency phenotype of beef cattle
(NUI Galway, 2019-03-06)Improving the feed efficiency of cattle is a method to increase profits while simultaneously reducing the environmental impact of beef production. Residual feed intake (RFI) is a measure of feed efficiency, calculated as ... -
The genomic architecture of nucleolar organiser regions on the short arms of human acrocentric chromosomes
(2015-09-29)Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequences. Nucleoli, the sites of ribosome biogenesis and key regulators of cellular growth and proliferation, form around NORs. ... -
Genomic integrity of human norovirus and F-RNA bacteriophage as detected by RT-qPCR and its relationship to infectivity before and after UV-treatment
(NUI Galway, 2018-05-10)A long-range RT (loRT) qPCR assay described to estimate levels of infectious virus was identified in the literature and applied to human norovirus (HuNoV) genogroups I and II (GI and GII), and the surrogate virus F-RNA ... -
The genomics of soil-persistant E. coli
(NUI Galway, 2020-11-19)Escherichia coli’s remarkable ability to thrive both in the gut and in soil confounds many assumptions made about the bacterium’s ecological niche specialisation, and a growing body of research has challenged the long-held ... -
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
(2016-09-21)The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ...