Browsing University of Galway Theses by Title
Now showing items 66-85 of 2276
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Analysis of cytokine expression in breast cancer
(2014-10-29)Introduction: It has long been recognized that cancer develops in sites of chronic inflammation. Tumours seem to seize molecular pathways seen in wound healing and the inflammatory response and as a consequence appear as ... -
Analysis of EMCCD gain estimation techniques for use in astronomical instruments
(NUI Galway, 2023-09-14)Electron-multiplied Charge Coupled Devices (EMCCDs) are used in many astro nomical instruments where they provide much improved signal to noise compared to conventional CCDs. However, the gain provided by electron-multiplication ... -
Analysis of gene regulation using high throughput genomics
(2012-10-23)The recent development of high-throughput genomics techniques and their subsequent applications have completely transformed the study of biology. The analysis, interpretation and storage of the resulting large volumes of ... -
Analysis of hepatic microRNA expression in postpartum dairy cows in negative energy balance
(2014-05-27)This thesis sets about to answer three research questions grounded in transcriptional regulation of hepatic genes in the high yielding postpartum dairy cow under negative energy balance (NEB). For this purpose we used ... -
Analysis of hepatic microRNA expression in postpartum dairy cows in negative energy balance
(2014-05-27)This thesis sets about to answer three research questions grounded in transcriptional regulation of hepatic genes in the high yielding postpartum dairy cow under negative energy balance (NEB). For this purpose we used ... -
An analysis of internal attacks on PTP-based time synchronization networks
(NUI Galway, 2021-12-21)The IEEE 1588 precision time protocol (PTP) is very important for many industrial sectors and applications that require time synchronization accuracy between computers down to microsecond and even nanosecond levels. ... -
Analysis of MiRNA Expression and Biomarker Potential in Common Diseases: Breast Cancer and Obesity
(2012-05-28)The two greatest health concerns worldwide at present are cancer and obesity; both of which continue to rise in incidence and are associated with high morbidity and mortality. Understanding the aetiology and mechanisms of ... -
Analysis of putative somatic mutations in 200,000 human exomes
(NUI Galway, 2023-09-19)Somatic mutations accumulate throughout life and contribute significantly to disease risk. While research into somatic mutation is well established in cancer, it is only in recent years that investigations into the ... -
Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Analysis of the behaviour of hybrid concrete lattice girder slabs during construction using laboratory and field testing
(NUI Galway, 2020-01-31)One of the emerging technologies in construction is the development of ‘smart structures’ which have sensors which will allow more efficient, resilient and sustainable structures to be designed and constructed. This research ... -
Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
An analysis of the health risks associated with international travel
(2015-01-28)This thesis, submitted for the award of a doctoral degree in Medicine, represents an attempt to collate all of my original research projects in travel medicine completed at NUI Galway. Chapter 1 presents four projects ... -
Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
(NUI Galway, 2018-09-28)Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ... -
Analysis of the role of Rho GTPases in epithelial cells
(2014-11-19)Rho GTPases are a family of small GTP binding proteins that function as molecular switches for the control of a variety of fundamental cellular processes, and therefore represent potentially vital proteins for skin ... -
Analytical and Computational Methods for Analyzing Feedback Structure in System Dynamics Models
(2012-07-10)The system dynamics approach is based on the observation that dynamic behaviour arises as a result of endogenous interactions, particularly the interplay of various feedback loops. There are many open questions relating ... -
Ancient Greek lexical semantics: Word meanings as a function of context
(NUI Galway, 2023-10-22)In 1989, Johannes Louw highlighted several problems in the study of Ancient Greek Lexical Semantics; 3 many remain unresolved. Louw’s rst diculty was that the etymology of a word is seldom a reliable indicator of ... -
Anglicisms in German radio media: A comparative study of the public service and private broadcasting sector
(NUI Galway, 2020-03-02)This thesis investigates the usage of anglicisms as mobile linguistic resources in both public service and private radio media in Germany. In previous research on anglicisms not much attention has been given to the medium ... -
Anisotropy resolved multi-dimensional emission spectroscopy (ARMES): a new tool for the quantitative and structural analysis of proteins
(NUI Galway, 2016-03-24)The quantitative and structural analysis of proteins is of great importance in numerous fields (from industrial to academic research). Requirements like ease of analysis, sample handling, robustness, analysis time, the ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) as a tool for biophysical analysis
(NUI Galway, 2021-10)The development of analytical tools for the biophysical analysis of biological samples is an area of tremendous application and potential. In this work the use and efficacy of an analytical methodology, known as anisotropy ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
(NUI Galway, 2018-11-14)Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ...