Browsing University of Galway Theses by Title
Now showing items 557-576 of 2275
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Diagnostic insights from twenty years of bilateral inferior petrosal sinus sampling for Cushings Disease at Mayo Clinic (1998-2018)
(NUI Galway, 2020-03-02)Pituitary-dependent Cushing syndrome (CS), referred to herein as Cushing Disease (CD), is the most common cause of endogenous CS. The challenge for diagnosing CD includes difficulty identifying the often small pituitary ... -
Dialectical dividends: fostering hybridity of new pedagogical practices and partnerships in science education and outreach
(2015-09-02)Internationally, science literacy has become socially and economically very important. Many European countries, including Ireland, stress that science and technology graduates are fundamental for economic growth. Nevertheless, ... -
Diet and renal outcomes
(2014-11)Chronic Kidney Disease (defined by decreased glomerular filtration rate and proteinuria) is associated with significant morbidity, increased cardiovascular risk and premature mortality. Advanced chronic kidney disease, ... -
Differences in immunogenicity between cancer mutation signatures shed light on immunoediting
(NUI Galway, 2024-04-15)Immunoediting is a process through which the immune system plays a role in shaping the mutational landscape of cancer and, consequently, in cancer progression. One critical aspect of immunoediting is the phenomenon known ... -
Differentiated thyroid cancer – Evaluation of contemporary management and novel risk assessment
(NUI Galway, 2021-07-08)Introduction Differentiated thyroid cancer (DTC) is a heterogeneous disease with a spectrum of phenotypes ranging from indolent to aggressive variants. The incidence of DTC has increased by 300% over the past 15 years ... -
The diffusion of global human resource information technology in the subsidiaries of a US multinational corporation
(2011-08-26)The majority of multinational corporations (MNC) utilise some form of global human resource information technology (GHRIT) to collect, store and analyse employee data. The literature suggests that the use of GHRIT has the ... -
Diffusion-based models for semantic relatedness
(NUI Galway, 2020-05-14)The assessment of semantic relatedness for a given pair of entities in a knowledge graph has become a critical step in a wide variety of artificial intelligence tasks, including but not restricted to fields such as machine ... -
Digital ensemble: exploring the design of technology-enhanced learning to mobilise and augment students' engagement with English literature
(2015-06-24)Students are disengaging from learning and literature learning in post primary education in Ireland due to an over-emphasis on rote learning practices and the constraints of high stakes, summative assessments (Chief ... -
Digital youth building digital capacity: The experience of rural communities in Manitoba, Canada
(NUI Galway, 2020-08-31)Today's digital society creates new realities and opportunities for rural communities. To fully take advantage of those digital opportunities, rural communities must build the capacity and culture to utilize digital ... -
Dihedral codes
(2009)In this thesis we give new constructions of a number of extremal type II codes. Algebraic proofs are provided that the constructions do in fact yield the codes. The codes are constructed using group rings of which the ... -
Disability, deficiency and excess: a critical re-examination of the construction, production and representations of physical disability in contemporary European film
(2014-06-26)This thesis critically investigates three contemporary European disability films to examine how representation and metaphor are used to present physical disability as deficient in comparison with the able-bodied ideal. The ... -
Discovery and characterization of novel poriferan biosynthetic pathways via next-generation sequencing
(NUI Galway, 2023-01-10)Sponges of the phylum Porifera are benthic, filter feeding animals which can be found in waters throughout the world. Because of these qualities, consistent challenges they face include exposure to ... -
Discrete vector fields and the cohomology of certain arithmetic and crystallographic groups
(2015-05-26)This thesis has two main topics: Arithmetic groups and Crystallographic groups. The work on arithmetic groups SL(2, Z[1/m]) was motivated by a question of Kevin Hutchinson and also a generalization of the paper "On the ... -
Discursive representations and translation practice: the constructed reader of Irish literature in Italian
(2013-05-31)This thesis approaches translation as a transformative act, which involves the decontextualisation of the source text and its recontextualisation within the target language culture. For literary works, the attempt to make ... -
Displacement and relocation in early modern Ireland: Studies of transplantation settlement in Connacht and Clare
(2012-10-26)This thesis is a study of three diverse Catholic families that received land during the mid seventeenth-century Cromwellian transplantation to and within Connacht and Clare. Transplantees, while being united in their ... -
Disruption of NEDD8 protein conjugation as a novel therapy for acute myeloid leukemia
(2012-08-15)The coordinated balance between the synthesis and degradation of proteins is an important regulator of cancer cell biology. The ubiquitin-proteasome system (UPS) is responsible for the timed destruction of many proteins ... -
Dissecting the evolution of resistance to microtubule hyper-stabilization
(NUI Galway, 2024-01-31)When microtubules are hyper-stabilized, they do not provide the proper tension at the kinetochore of the metaphase chromosomes. Low tension leads to the activation of the spindle assembly checkpoint which stops cells ... -
Dissecting the monster: mapping discourses of medicine, ethics, and monstrosity in the Victorian Penny Blood
(2017-02-02)This research analyses a set of specimens of penny blood literature from the point of view of medical history, with the goal of providing an examination of the genre in relation to its historical context. In so doing, it ... -
Dissecting the pan-placodal gene regulatory network reveals novel interactions driving sense organ development in vertebrates
(2016-02-17)The genes encoding the transcription factor Six1, and its co-factor Eya1 together mark the embryonic territory - the pan-placodal ectoderm (PPE) - that gives rise to most cranial sense organs in vertebrates. Mutation of ... -
Distinct mechanisms underlie oral versus aboral regeneration in the cnidarian hydractinia echinata
(2014-10-24)Distinct mechanisms underlie oral versus aboral regeneration in Hydractinia echinata. Head regeneration is preceded by stem cell migration, proliferation and blastema formation. After decapitation stem cells migrate from ...