Browsing University of Galway Theses by Title
Now showing items 533-552 of 2275
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Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ... -
Development of efficient data assimilation methods for solute transport problems
(NUI Galway, 2018-09-18)The solution of marine contaminant transport problems is a significant research topic in civil engineering. Typically, the problem is represented as a partial differential equation described by the non-stationary, ... -
The Development of Farmed Cod in Ireland
(2012-05-25)This study is interlinked with the work programme of the EIROCD project. Utilising historical data and empirical experimental approaches, various aspects of development, growth and phenotypic plasticity of North Atlantic ... -
Development of filtration technologies for effective, cost-efficient and robust water treatment
(2016-08-12)The provision of high quality, potable water in a sustainable and effective manner is a key challenge for water engineers, scientists, and policy makers. Urbanisation and industrial development, along with population ... -
Development of glucose-oxidising enzyme electrodes for application in glucose|oxygen powered enzymatic fuel cells
(2016-02)The objective of this thesis is to investigate different strategies for the optimisation of biocatalytic anodes with a view to developing a semi- or fully implantable, miniature, membrane-less enzymatic fuel cell via ... -
Development of long-term daily maximum and minimum air temperature series and assessment of past extreme air temperature events in Ireland
(NUI Galway, 2021-05-06)Despite the rich heritage of meteorological observations registered in Ireland, prior to this PhD research, numerous historical daily air temperature records remained only in paper data sources across multiple archives, ... -
Development of Mediated Enzymatic Fuel Cells for Operation in Blood
(2013-07)The process of enzymatic catalysis of glucose oxidation releases electrons which, when harnessed to flow through a circuit, may be utilised to power devices. This principle has driven research towards the goal of providing ... -
Development of mid-infrared spectroscopic methods for the determination of soil chemical quality in tillage fields
(NUI Galway, 2021-04-30)Healthy soils are the foundation for a prosperous future by providing nutrition, clean water, and the basis for all biodiversity on land. But soil health is threatened by soil degradation and climate change. To improve ... -
Development of multiplex real-time PCR assays for the detection and identification of ESKAPE pathogens and their closely related species complexes: Toward reducing the occurrence of healthcare-associated infection using enhanced surveillance of clinical and environmental samples
(NUI Galway, 2023-08-18)Microorganisms have the ability cause a wide range of infections in humans - from superficial skin infections to invasive pneumonia and sepsis. Advancements in medical technology, as well as an expanding global population, ... -
Development of new benchmarking systems for wastewater treatment facilities
(2017-06-30)In the European Union, the Urban Waste Water Treatment Directive (UWWTD) of 1991 sets out the requirements for the collection, treatment and discharge of wastewater, to protect the environment from the adverse effects of ... -
Development of next generation MSC therapeutics for critical limb ischaemia
(2015-02-19)Cell therapy with mesenchymal stem cells (MSCs) is being explored as a treatment for many ischaemic conditions of unmet medical need, such as critical limb ischaemia. MSC transplantation in humans has occurred in both ... -
Development of non-metallic and adhesive-free timber-timber moment connections using compressed wood connectors
(NUI Galway, 2020-09-30)Increasing the sustainability credentials of building materials is one of the main challenges in the built environment. Over the last few decades, there has been a renewed interest in the use of timber in construction in ... -
Development of novel biomaterials and medical devices to improve diabetes treatment and ambient cell transportation
(NUI Galway, 2023-02-08)Diabetes mellitus is a global pandemic affecting to more than 500 million people worldwide, with Type 1 diabetics being the most at risk due to life-threatening hyper and hypoglycaemic complications. Islet transplantation ... -
Development of novel culture independent nucleic acid based diagnostics technologies for the detection and identification of microbial contaminants in building water distribution and premise plumbing systems
(2015-02-22)Water is a vital component of the industrial, pharmaceutical and healthcare sectors. In industrial and pharmaceutical sectors water is a commonly used raw material, solvent and ingredient. While in healthcare facilities ... -
Development of novel nucleic acid diagnostics technologies for the detection of predominant microorganisms associated with bacterial meningitis
(2017-01-13)With an estimated 1.2 million cases annually worldwide, bacterial meningitis is a medical emergency and primary prevention as well as accurate diagnosis and treatment of this often fatal disease is paramount. The ... -
The Development of Process Indicators for Science Communication using Social Marketing and Innovation Theory
(2013-08-23)Science surrounds our daily lives and is an integral component to the development of sustainable communities and societies. Science also contributes to the competitiveness and advancement of economies through their governing ... -
Development of rapid spectroscopic methods for the analysis of cell culture media
(NUI Galway, 2014-11-28)Industrial scale cell culture is used for the production of many therapeutic agents such as protein and vaccines. Cell culture medium is a vital raw material used in these production processes. Formulation analysis of the ... -
The development of reliable chemical kinetic mechanisms to describe the oxidation of natural gas blends containing C1– C7 n-alkanes and the effects of NOx on natural gas oxidation at practical combustor relevant conditions
(NUI Galway, 2022-03-01)The use of natural gas (NG) for transportation and heavy-duty power generation applications has led to an increase in demand for conventional and non-conventional NG sources. Moreover, techniques such as exhaust gas ... -
The development of reporters to measure the general stress response in Listeria monocytogenes: population and single cell studies on the activation of SigmaB
(2012-09-28)The foodborne pathogen Listeria monocytogenes has a remarkable ability to persist and grow in harsh environments, including the human gastrointestinal tract. This attribute is regulated, at least partly, by the alternative ... -
Development of Simplified NIPAm-based Thermoresponsive Films for Cell Preservation, Expansion and Differentiation
(2013-12-16)Traditional cell recovery methodologies cleave cell-to-cell junctions and thus the recovery of an intact cell sheet for use in tissue engineering is rendered impossible. Additionally, these traditional cell detachment ...