Browsing University of Galway Theses by Title
Now showing items 1207-1226 of 2276
-
An investigation of the relationship between international law, international politics and the state using Syria as a case study
(NUI Galway, 2018-11-20)The thesis investigates the relationship between international law, international politics and the state using Syria as a case study. Syria was chosen because it has historically been the site of regional and international ... -
An investigation of the role of body-worn inertial sensing in the analysis of elite swimming performance
(2017-09-29)Swimming is a technically demanding sport that requires ongoing quantitative assessment in order to monitor technical progression and improvements in performance. Traditional methods of monitoring a swimmer’s technique ... -
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ... -
Investigation of the role of nuclear factor kappa-B in mediating the effects of hypercapnic acidosis and mesenchymal stem cells in ventilation induced lung injury
(NUI Galway, 2016-11-08)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ... -
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
(NUI Galway, 2021-12-30)Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ... -
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
(2012-11)Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ... -
Investigation of the structure and function of the metal transporter CzrB from Thermus thermophilus and the molecular chaperone trigger factor from Psychrobacter frigidicola by X-ray crystallography
(2014-09-26)A crystallographic approach was taken to investigate the structure and function of two proteins of interest previously isolated in our research group and identified as having potential application in improving the production ... -
Investigation of the therapeutic potential of mesenchymal stem/stromal cells in preclinical models of systemic sepsis
(NUI Galway, 2020-10-29)Introduction: Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ... -
An investigation of the viscoelastic and mechano-sorptive creep behaviour of reinforced timber elements
(2016-12-15)The reinforcement of timber using fibre reinforced polymer (FRP) rods or plates is widely accepted as an effective method of increasing the strength and stiffness of members. Across Europe, this technology has been used, ... -
Investigation of transmission of human respiratory pathogens using whole genome sequencing
(NUI Galway, 2023-06-20)This doctoral thesis explores the role of whole genome sequencing in the investigation of transmission of human respiratory pathogens. It is a “PhD thesis by publication” which consists primarily of three published ... -
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ... -
An investigation on the use of sensory electrical stimulation as a cueing therapy to ameliorate on-state freezing of gait in people with Parkinson's Disease
(NUI Galway, 2021-05-04)People with Parkinson’s (PwP) currently face a significant challenge in managing on-state Freezing of Gait (FoG). While auditory and visual cueing therapies have been shown to ameliorate on-state FoG, studies often show ... -
Investigations into assimilating high-frequency radar data into a three-dimensional hydrodynamic model of a wind-dominated coastal water body
(2015-10)Accurate forecasting of surface currents in coastal waters is of great importance for operations such as search and rescue operations and marine energy extraction. Numerical models and measurements are two powerful ... -
Investigations into soil microbiome stability in the face of agriculture and climate change related perturbations
(NUI Galway, 2017-11-05)Soils and the vital ecosystem services performed by their indigenous microbiota are under increasing pressure from anthropogenic stresses and climate change. In an effort to understand how the provision of soil ecosystem ... -
Investigations of spicules and spicule formation in Haplosclerida (Porifera, Demospongiae) using a multidisciplinary approach
(NUI Galway, 2019-01-09)Sponges are simple animals and their body is formed by different cell types and a dense skeleton either of collagen, chitin or spicules made of amorphous silica or calcium carbonate that they secrete. The phylum Porifera ... -
Involvement of toll-like receptor 4 in concanavalin A-induced liver injury: Investigation on structure and permeability of intestinal wall
(NUI Galway, 2021-08-31)Concanavalin A (ConA) induces T cell-mediated liver injury in mice associated with altered microcirculation, cytokine signalling cascades, and increased intestinal permeability. Toll-like receptor 4 (TLR4) acts as a sensor ... -
Involving children and young people in social research: navigating the balance between protection and participation
(2016-10-14)This thesis is an article-based PhD. Against the backdrop of the almost universal acceptance of the UN Convention on the Rights of the Child and the scholarly works comprising the ‘new social studies of childhood’, the ... -
Iodine in Seaweeds - Physiological Significance and Implications for Climate and Health
(2013-01-18)Iodine-rich macroalgae inhabit the subtidal on coasts in temperate regions. The algae-driven release of iodine into the environment has major implications for the biogeochemical iodine cycle a ffecting atmospheric chemistry ... -
Irelands’ hidden pharmacy: Marine biodiscovery applied to deep-sea sponges and corals
(NUI Galway, 2022-06-08)Natural products have provided over 60% of our medicines to date, but their search has focused on easy to access habitats, leaving the marine realm underexplored. The deep-sea, which is the world’s largest biome and ... -
Ireland’s agri-food and drink sector: The correlation between eWOM initiatives and employee brand advocacy
(NUI Galway, 2020-01-20)The Irish agri-food and drink sector has a rich heritage. It is Ireland’s largest indigenous industry, employing 8.4% of the working population and generating an annual turnover of €27.5bn. SMEs within the sector use social ...