Browsing University of Galway Theses by Title
Now showing items 1035-1054 of 2273
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Identification of novel factors that promote trinucleotide repeat instability
(2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ... -
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ... -
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated leukemic blast cell clones. ... -
Identifying novel strategies to re-engage the apoptotic pathway for the treatment of cancer
(2014-09-30)In chapter two we demonstrate that in non-transformed cells multiple signalling pathways control TRAIL resistance and they act in a redundant manner. This is contrary, however, to the resistance mechanisms found in tumour ... -
Identifying, annotating, and filtering arguments and opinions in open collaboration systems
(2013-09-13)The World Wide Web enables large-scale collaboration, even between groups of individuals previously unknown to one another. These collaborations produce tangible outputs, such as encyclopedias (Wikipedia), electronic books ... -
Identity Formation Among Teenaged Members of the Muslim Population of Ballyhaunis, Co. Mayo
(2012-08-29)Younger members of Muslim populations in Western society are placed at the frontline of the immigration process. As a result of daily school attendance and exposure to the media they are often heavily influenced by the ... -
Illegal territoriality in international law: the interaction and enforcement of the law of belligerant occupation through other territorial regimes
(2014-08-30)This work examines the place and function of the international law of belligerent occupation its interplays with other public international law regimes and argues that the co-application of these regimes, as well as an ... -
(Im)Possibility of Utopia: Aldous Huxley and Michel Houellebecq
(NUI Galway, 2023-08-17)This thesis examines the connections between ambivalence and Utopianism through the writings of Aldous Huxley and Michel Houellebecq. By conducting a comprehensive analysis of the authors’ seminal works, this study ... -
Image and video quality in the automotive environment
(2016-05-12)This thesis is concerned with the development of methodologies for image and video quality assessment for the automotive environment, and the use of those methodologies for evaluating the effect of image and video ... -
Image super-resolution for consumer thermal cameras
(NUI Galway, 2019-01-21)This thesis attempts to solve a problem currently faced by consumer-grade thermal cameras. Consumers have grown accustomed to the high pixel counts and high resolution offered by the modern smartphone, while the performance ... -
Images and representations of the sea in early medieval Hiberno-Latin and vernacular literature: studies in intertextuality and innovation
(2017-02-23)This research takes the sea and its creatures as the common focus for an investigation of a series of thematically linked early medieval texts’ interactions with each other and with texts ranging from contemporaneous Insular ... -
An immersive virtual reality behaviour change intervention to support retired and non-working adults to reduce prolonged bouts of sedentary activity
(NUI Galway, 2024-01-25)Background. It is currently understood that prolonged daily sedentary behaviour is independently associated with multiple morbidities and mortality across the adult lifespan. Epidemiological evidence suggests that older ... -
Immunogenicity of allogeneic mesenchymal stem cells
(2016-10-20)Allogeneic mesenchymal stem cells (allo-MSC) are a promising “off-the-shelf” therapy and are often cited as failing to elicit anti-donor immune responses. Intra-muscular (IM) administration may be the optimal route for ... -
Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis
(2015-03-06)Although osteoarthritis (OA) is typically characterised by the loss or damage to articular cartilage, inflammation of the synovial membrane is now recognised as a prevalent feature believed to contribute to both symptoms ... -
Immunomodulation in mesenchymal stem cell therapy for osteoarthritis: mechanistic insights on the role of cell death and engraftment
(NUI Galway, 2018-11-02)Osteoarthritis (OA) is a degenerative pathology of the articular cartilage causing chronic pain and disability in millions of individuals. In OA synovia, resident macrophages and infiltrated lymphocytes contribute to the ... -
Immunomodulation of the T-helper 17 Cell Lineage by Mesenchymal Stem Cells
(2012-11-20)T-helper 17 (Th17) cells play a pathogenic role in multiple sclerosis, inflammatory bowel disease, psoriasis, acute kidney injury, glomerulonephritis and transplant rejection. Mesenchymal stem cells (MSCs) are immunosuppressive ... -
The impact of alcohol consumption on brain networks: Investigating differential effects in bipolar disorder
(NUI Galway, 2022-03-30)Background: Widespread alterations to cortical regions particularly in areas related to reward processes have been described following non-dependent alcohol use and independently in bipolar disorder (BD). Additionally, ... -
The impact of chemically amended pig slurry on surface runoff, leachate and greenhouse gasses.
(2013-08-27)In Ireland, the pig industry is concentrated in a small number of counties. Pig farms typically have a high stocking rate. Therefore, the disposal of slurry in a cost-effective and environmentally-responsible way is a ... -
The impact of childhood trauma on structural brain connectivity in schizophrenia: A diffusion MRI and network based study
(NUI Galway, 2021-12-29)Schizophrenia is a severe and heterogeneous neuropsychiatric disorder affecting approximately 1% of the world’s population. In recent years, exposure to childhood trauma has been established as a prominent environmental ...