Now showing items 1-2 of 2

  • Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization 

    Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)
    During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...
  • Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response 

    Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)
    The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ...