Browsing School of Natural Sciences by Subject "TrkA"

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    • Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity 

      Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)
      Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ...

    • Nerve Growth Factor in Cancer Cell Death and Survival 

      Molloy, Niamh H.; Read, Danielle E.; Gorman, Adrienne M. (MDPI, 2011-02)
      One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ...