Browsing School of Natural Sciences by Author "Chakravarthy, Reka"
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Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity
Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ... -
Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells
Chakravarthy, Reka; Mnich, Katarzyna; Gorman, Adrienne M. (Elsevier, 2016)Triple negative breast cancer [TNBC] cells are reported to secrete the neurotrophin nerve growth factor [NGF] and express its receptors, p75 neurotrophin receptor [p75(NTR)] and TrkA, leading to NGF-activated pro-survival ...