Browsing School of Natural Sciences at NUI Galway by Title
Now showing items 1-20 of 47
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Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells
(American Society for Microbiology, 2004-03)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
An assessment of RNA content in Prymnesium parvum, Prymnesium polylepis, cf. Chattonella sp. and Karlodinium veneficum under varying environmental conditions for calibrating an RNA microarray for species detection
(Wiley, 2014-02-03)Traditional methods of identification and enumeration can be somewhat ambiguous when identifying phytoplankton that requires electron microscopic examination to verify specific morphological features. Members of the genus ... -
Bcl-2 family on guard at the ER
(American Physiological Society, 2009)The endoplasmic reticulum (ER) is the main site for protein folding, lipid biosynthesis and calcium storage in the cell. Disturbances of these critical cellular functions lead to ER stress. The ER responds to disturbances ... -
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
(American Society for Microbiology, 2008-01)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
Comparative genome analysis identifies novel nucleic acid diagnostic targets for use in the specific detection of Haemophilus influenzae
(Elsevier, 2015-06-23)Haemophilus influenzae is recognised as an important human pathogen associated with invasive infections, including bloodstream infection and meningitis. Currently used molecular-based diagnostic assays lack specificity in ... -
Comparison of established diagnostic methodologies and a novel bacterial smpB real-time PCR assay for the specific detection of haemophilus influenzae associated with respiratory tract infections
(American Society for Microbiology, 2015-06-23)Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a rapid H. influenzae diagnostic assay that would allow for the implementation of infection control ... -
Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
(American Society for Microbiology, 2000-09)A type III secretion-translocation system allows Yersinia adhering at the surface of animal cells to deliver a cocktail of effector Yops (YopH, -O, -P, -E, -M, and -T) into the cytosol of these cells. Residues or codons 1 ... -
Contrasting responses to nutrient enrichment of prokaryotic communities collected from deep sea sites in the Southern Ocean
(MDPI Open-Access Journals, 2013-09-13)Abstract: Deep water samples (ca. 4,200 m) were taken from two hydrologically-similar sites around the Crozet islands with highly contrasting surface water productivities. Site M5 was characteristic of high productivity ... -
Control of transfer and weak closure in fusion systems
(2010)We show that K¿ and K¿ control transfer in every fusion system on a finite p-group when p ¿ 5, and that they control weak closure of elements in every fusion system on a finite p-group when p ¿ 3. This generalizes resultsof ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating MiRNAs
(Public Library of Science, 2015-09-10)Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed as biomarkers ... -
Expansions of CAG·CTG repeats in immortalized human astrocytes.
(Oxford University Press, 2007)Expansions of trinucleotide repeats (TNRs) are the genetic cause for a number of neurodegenerative disorders. In some of these diseases, ongoing somatic expansions in the brain are thought to contribute to disease progression. ... -
High-resolution analysis of parent-of-origin allelic expression in the Arabidopsis endosperm.
(2011)Genomic imprinting is an epigenetic phenomenon leading to parent-of-origin specific differential expression of maternally and paternally inherited alleles. In plants, genomic imprinting has mainly been observed in the ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
(2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
(American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds
(2011)Background: Epigenetic regulation of gene dosage by genomic imprinting of some autosomal genes facilitates normal reproductive development in both mammals and flowering plants. While many imprinted genes have been identified ... -
Identifying the sources and sinks of CDOM/FDOM across the Mauritanian Shelf and their potential role in the decomposition of superoxide (O2- )
(Frontiers Media, 2016-08-03)Superoxide (O−2O2-) is a short lived reactive oxygen species (ROS) formed in seawater by photochemical or biological sources, it is important in the redox cycling of trace elements and organic matter in the ocean. The ... -
Intracellular accumulation of high levels of gamma-aminobutyrate by Listeria monocytogenes 10403S in response to low pH: uncoupling of gamma-aminobutyrate synthesis from efflux in a chemically defined medium
(American Society for Microbiology, 2010-06)It is well established that the glutamate decarboxylase (GAD) system is central to the survival of Listeria monocytogenes at low pH, both in acidic foods and within the mammalian stomach. The accepted model proposes that ... -
The isolation of strains of Bacillus subtilis showing improved plasmid stability characteristics by means of selective chemostat culture
(1988-03-23)A PUB 110-derived plasmid encoding chloramphenicol resistance, kanamycin resistance and high-temperature alpha-amylase showed a high degree of segregational instability when inserted into Bacillus subtilis. In an attempt ... -
Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: Apoptosis induction by TRAIL
(American Society for Biochemistry and Molecular Biology, 2012)Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ... -
LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells
(American Society for Microbiology, 1998-06)Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of ...