Now showing items 1-3 of 3

    • Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression 

      Whitton, Laura; Cosgrove, Donna; Clarkson, Christopher; Harold, Denise; Kendall, Kimberley; Richards, Alex; Mantripragada, Kiran; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Hartmann, Annette; Konte, Betina; Rujescu, Dan; Gill, Michael; Corvin, Aiden; Rea, Stephen; Donohoe, Gary; Morris, Derek W. (Wiley, 2016-10-20)
      Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, and synaptic plasticity. These ...
    • Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders 

      Kenny, Elaine M.; Cormican, Paul; Furlong, Sarah; Heron, Eleisa; Kenny, Graham; Fahey, Ciara; Kelleher, Eric; Ennis, Sean; Tropea, Daniela; Anney, Richard; Corvin, Aiden P.; Donohoe, Gary; Gallagher, Louise; Gill, Michael; Morris, Derek W. (Springer Nature, 2013-10-15)
      Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that may share an underlying pathology suggested by shared genetic risk variants. We sequenced the exonic regions of 215 genes ...
    • Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia 

      Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Donohoe, Gary; Gill, Michael; Corvin, Aiden; Morris, Derek W. (Wiley, 2019-02-23)
      Genome‐wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of ...