Browsing School of Natural Sciences by Author "Fahey, Laura"
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Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons
Cosgrove, Donna; Whitton, Laura; Fahey, Laura; Ó Broin, Pilib; Donohoe, Gary; Morris, Derek W. (Oxford University Press (OUP), 2020-09-25)Myocyte enhancer factor 2 C (MEF2C) is an important transcription factor during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within MEF2C are associated with ... -
Genes regulated by BCL11B during T‐cell development are enriched for de novo mutations found in schizophrenia patients
Fahey, Laura; Donohoe, Gary; Ó Broin, Pilib; Morris, Derek W. (Wiley, 2020-07-29)While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ.BCL11B, associated with SCZ in genome-wide association study (GWAS), is a ...