Browsing School of Natural Sciences by Author "http://dx.doi.org/10.13039/501100002081"
Now showing items 1-7 of 7
-
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function
Flynn, Mairéad; Whitton, Laura; Donohoe, Gary; Morrison, Ciaran G.; Morris, Derek W. (Oxford University Press (OUP), 2019-12-23)Mutations in genes that encode centrosomal/ciliary proteins cause severe cognitive deficits, while common single-nucleotide polymorphisms in these genes are associated with schizophrenia (SZ) and cognition in genome-wide ... -
Antibacterial potential of an antimicrobial agent inspired by peroxidase-catalyzed systems
Tonoyan, Lilit; Fleming, Gerard T. A.; Mc Cay, Paul H.; Friel, Ruairi; O'Flaherty, Vincent (Frontiers Media, 2017-05-02)Antibiotic resistance is an increasingly serious threat to global health. Consequently, the development of non-antibiotic based therapies and disinfectants, which avoid induction of resistance, or cross-resistance, is of ... -
A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis
Kumar Maharana, Santosh; Schlosser, Gerhard (BioMed Central, 2018-06-16)Background: The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop ... -
Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons
Cosgrove, Donna; Whitton, Laura; Fahey, Laura; Ó Broin, Pilib; Donohoe, Gary; Morris, Derek W. (Oxford University Press (OUP), 2020-09-25)Myocyte enhancer factor 2 C (MEF2C) is an important transcription factor during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within MEF2C are associated with ... -
Glycomics microarrays reveal differential in situ presentation of the biofilm polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus cell surfaces
Flannery, Andrea; Le Berre, Marie; Pier, Gerald B.; O’Gara, James P.; Kilcoyne, Michelle (MDPI, 2020-04-02)The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative ... -
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
Tonoyan, Lilit; Boyd, Aoife; Fleming, Gerard T.A.; Friel, Ruairi; Gately, Carol M.; Mc Cay, Paul H.; O'Flaherty, Vincent (Elsevier, 2018-04-03)Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ... -
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ...