Browsing College of Science by Author "Civati, Francesco"
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A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations
Pallipurath, Anuradha R.; Civati, Francesco; Sibik, Juraj; Crowley, Clare; Zeitler, J. Axel; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2017-06-08)Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on ... -
Conversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attrition
Civati, Francesco; Erxleben, Andrea; Kellehan, Seamus; McArdle, Patrick (American Chemical Society, 2019-02-01)We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution ... -
Manipulating cocrystal size and morphology using a combination of temperature cycling and additives
Civati, Francesco; Svoboda, Vaclav; Urwin, Stephanie Jane; McArdle, Patrick; Erxleben, Andrea; Croker, D.; ter Horst, Joop (American Chemical Society, 2020-11-20)A cooling crystallization of benzoic acid and isonicotinamide in ethanol yields the 1:1 cocrystal with an extreme needle-like morphology with an initial mean aspect ratio of ∼10 and a size of ∼64 μm. We demonstrate that ... -
Tailoring cocrystal and salt formation and controlling the crystal habit of diflunisal
Pallipurath, Anuradha R.; Civati, Francesco; Eziashi, Magdalene; Omar, Elaf; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2016-09-26)Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long needles has been achieved by breaking the stacking effect with the help of coformers. Eight new cocrystals are reported, along ...