Now showing items 1-8 of 8

    • In vivo correlation mapping microscopy 

      McGrath, James; Alexandrov, Sergey; Owens, Peter; Subhash, Hrebesh; Leahy, Martin (Society of Photo-optical Instrumentation Engineers (SPIE), 2016-03)
      To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical ...
    • Label free ultra-sensitive imaging with sub-diffraction spatial resolution 

      Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)
      In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ...
    • Microcirculation imaging based on full-range high-speed spectral domain correlation mapping optical coherence tomography 

      Subhash, Hrebesh M.; Leahy, Martin (SPIE (International Society for Optics and Photonics, 2014)
      Microcirculation imaging is a key parameter for studying the pathophysiological processes of various disease conditions, in both clinical and fundamental research. A full-range spectral-domain correlation mapping optical ...
    • Nano-sensitive optical coherence tomography 

      Alexandrov, Sergey; Subhash, Hrebesh M.; Zam, Azhar; Leahy, Martin (Royal Society of Chemistry, 2014)
      Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and ...
    • Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures 

      Subhash, Hrebesh M.; Leahy, Martin; Alexandrov, Sergey (IOP Science, 2014-03-06)
      We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach ...
    • Novel approach for label free super-resolution imaging in far field 

      Alexandrov, Sergey; McGrath, James; Hrebesh, Subhash; Leahy, Martin (Nature Publishing Group, 2015)
      Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the structures with high resolution. Recently, the ...
    • Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization 

      Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)
      Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...
    • Tissue viability imaging of skin microcirculation following exposure to Cold Air (-110°C) and Cold Water (8°C) 

      Leahy, Martin (CIAFEL, 2013)
      Cryotherapy is currently used in various clinical, rehabilitative and sporting settings. However, very little is known regarding the impact of cooling on the microcirculatory response. Objectives: The present study sought ...