Browsing College of Science by Author "Lahue, Robert S."
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Expansions of CAG·CTG repeats in immortalized human astrocytes.
Lahue, Robert S. (Oxford University Press, 2007)Expansions of trinucleotide repeats (TNRs) are the genetic cause for a number of neurodegenerative disorders. In some of these diseases, ongoing somatic expansions in the brain are thought to contribute to disease progression. ... -
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
Lahue, Robert S. (Springer, 2008)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ... -
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
Lahue, Robert S. (OUP, 2008)Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ... -
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
Lahue, Robert S. (2008)Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ...