Browsing College of Science by Author "Aljohani, Marwah"

Now showing items 1-7 of 7

    • Cocrystal forms of the BCS class IV drug sulfamethoxazole 

      Alsubaie, Moneerh; Aljohani, Marwah; Erxleben, Andrea; McArdle, Patrick (American Chemical Society, 2018-05-23)
      Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve ...

    • A comprehensive cocrystal screening study of chlorothiazide 

      Aljohani, Marwah; Pallipurath, Anuradha R.; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2017-09-01)
      Cocrystal formation of chlorothiazide (ctz) was screened with a variety of coformers with carboxyl, amide, hydroxyl, sulfonamide, pyridine, amidine, and amine functional groups. New cocrystals with acetamide (aca), benzamide ...

    • Dual-drug amorphous formulation of gliclazide 

      Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (Taylor and Francis, 2021-02-01)
      Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ...

    • Hydrogen bonding networks and solid-state conversions in benzamidinium salts 

      Kamali, Naghmeh; Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (2015-07-14)
      Ten benzamidinium salts of carboxylic acids, amides, and sulfonamides have been crystallized from solution. Single-crystal X-ray analyses revealed various hydrogen bonding motifs which ate discussed in terms of supramolecular ...

    • Influence of excipients on cocrystal stability and formation 

      Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020-05-26)
      Cocrystal formation is widely used to modify and optimize the physicochemical properties of an active pharmaceutical ingredient (API). However, the stability of cocrystals toward formulation with excipients is little ...

    • Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide 

      Aljohani, Marwah; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2019-02-23)
      The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ...

    • The very different effect of water on nucleation, crystallization, and hydrate stability of zingerone and vanillate esters 

      Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020-01-09)
      Vanillin and vanillate esters are widely used as flavorings in the food industry, and the vanillin derivative zingerone is one of the compounds found in the spice ginger. Neither the growth of single crystals of zingerone ...