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dc.contributor.authorKulkarni, Mangeshen
dc.contributor.authorGriser, Udoen
dc.contributor.authorO'Brien, Timothyen
dc.contributor.authorPandit, Abhayen
dc.date.accessioned2010-10-14T09:14:33Zen
dc.date.available2010-10-14T09:14:33Zen
dc.date.issued2010-01-01en
dc.identifier.citationKulkarni, M., Greiser, U., O'Brien, T., & Pandit, A. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends in Biotechnology, 28(1), 28-36.en
dc.identifier.issn0167-7799en
dc.identifier.urihttp://hdl.handle.net/10379/1335en
dc.description.abstractIn the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome¿scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.en
dc.formatapplication/pdfen
dc.publisherElsevieren
dc.subjectNon-viral gene deliveryen
dc.subjectNetwork of Excellence for Functional Biomaterialsen
dc.titleLiposomal gene delivery mediated by tissue-engineered scaffoldsen
dc.typeArticleen
dc.local.publishedsourcehttp://www.sciencedirect.com/science/article/B6TCW-4XM99F4-1/2/10e81833ae08e38bb0cb0ca9a0667bb8en
dc.description.peer-reviewedpeer-revieweden
dc.contributor.funderScience Foundation Irelanden
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