dc.contributor.author | Kulkarni, Mangesh | en |
dc.contributor.author | Griser, Udo | en |
dc.contributor.author | O'Brien, Timothy | en |
dc.contributor.author | Pandit, Abhay | en |
dc.date.accessioned | 2010-10-14T09:14:33Z | en |
dc.date.available | 2010-10-14T09:14:33Z | en |
dc.date.issued | 2010-01-01 | en |
dc.identifier.citation | Kulkarni, M., Greiser, U., O'Brien, T., & Pandit, A. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends in Biotechnology, 28(1), 28-36. | en |
dc.identifier.issn | 0167-7799 | en |
dc.identifier.uri | http://hdl.handle.net/10379/1335 | en |
dc.description.abstract | In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome¿scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions. | en |
dc.format | application/pdf | en |
dc.publisher | Elsevier | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Non-viral gene delivery | en |
dc.subject | Network of Excellence for Functional Biomaterials | en |
dc.title | Liposomal gene delivery mediated by tissue-engineered scaffolds | en |
dc.type | Article | en |
dc.local.publishedsource | http://www.sciencedirect.com/science/article/B6TCW-4XM99F4-1/2/10e81833ae08e38bb0cb0ca9a0667bb8 | en |
dc.description.peer-reviewed | peer-reviewed | en |
dc.contributor.funder | Science Foundation Ireland | en |
nui.item.downloads | 791 | |