Now showing items 1-3 of 3

  • Liposomal gene delivery mediated by tissue-engineered scaffolds 

    Kulkarni, Mangesh; Griser, Udo; O'Brien, Timothy; Pandit, Abhay (Elsevier, 2010-01-01)
    In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as ...
  • Non-viral gene therapy for myocardial engineering 

    Holladay, Carolyn A.; O'Brien, Timothy; Pandit, Abhay (John Wiley & Sons, Ltd., 2010-05)
    Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ...
  • Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro 

    McMahon, Siobhan; Nikolskaya, Natalia; Ní Choileain, Siobhan; Hennessy, Niamh; O'Brien, Timothy; Rochev, Yury (Wiley, 2011-11-01)
    Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried ...