Now showing items 1-15 of 15

    • Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors 

      Dwyer, Róisín M.; Bergert, Elizabeth R.; O'Connor, Michael K.; Gendler, Sandra J.; Morris, John C. (Mary Ann Liebert, 2006-06-15)
      Pancreatic cancer is the fourth leading cause of cancer death in the United States. It is highly aggressive with no uniformly effective chemotherapy available for metastatic disease. The sodium–iodide symporter (NIS) is a ...
    • Circulating MicroRNAs in cancer 

      O’Brien, Killian P.; Ramphul, Eimear; Howard, Linda; Gallagher, William M.; Malone, Carmel; Kerin, Michael J.; Dwyer, Róisín M. (Humana Press, 2016-11-09)
      It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ...
    • Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379 

      O’Brien, K. P.; Khan, S.; Gilligan, K. E.; Zafar, H.; Lalor, P.; Glynn, C.; O’Flatharta, C.; Ingoldsby, H.; Dockery, P.; De Bhulbh, A.; Schweber, J. R.; St John, K.; Leahy, M.; Murphy, J. M.; Gallagher, W. M.; O’Brien, T.; Kerin, Michael J.; Dwyer, Róisín M. (Springer Nature, 2018-01-25)
      Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...
    • Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation 

      Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)
      Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...
    • Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo 

      Potter, Shirley M.; Dwyer, Róisín M.; Hartmann, Marion C.; Khan, Sonja; Boyle, Marie P.; Curran, Catherine E.; Kerin, Michael J. (Springer, 2011-02-23)
      Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ...
    • Mesenchymal stem cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer 

      Dwyer, Róisín M.; Ryan, James; Havelin, Ronan J.; Morris, John C.; Miller, Brian W.; Liu, Zhonglin; Flavin, Richard; O'Flatharta, Cathal; Foley, Mark J.; Barrett, Harrison H; Murphy, J. Mary; Barry, Frank P; O'Brien, Timothy; Kerin, Michael J. (AlphaMed Press, 2011-05-23)
      Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity to bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study ...
    • Mesenchymal Stem Cells (MSCs) and cancer: tumour specific delivery vehicles or therapeutic targets? 

      Dwyer, Róisín M.; Kerin, Michael J. (Mary Ann Liebert, 2010-09-30)
      Mesenchymal stem cells (MSCs) are a subset of nonhematopoietic multipotent cells found primarily within the bone marrow stroma. The ability of MSCs to specifically home to sites of tumors and their metastases, while escaping ...
    • Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications 

      Hogan, Niamh M.; Dwyer, Róisín M.; Joyce, Myles R.; Kerin, Michael J. (Wiley, 2012-01-30)
      Mesenchymal stem cells (MSCs) are nonhematopoietic multipotent adult stem cells. They have been shown to have a natural tropism for many tumors types, including colorectal, and are capable of escaping host immune surveillance. ...
    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...
    • Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT) 

      Martin, F. T.; Dwyer, Róisín M.; Kelly, J.; Khan, S.; Murphy, J. M.; Curran, C.; Miller, N.; Hennessy, E.; Dockery, P.; Barry, F. P.; O'Brien, T.; Kerin, Michael J. (Springer, 2010-01-20)
      Bone marrow-derived mesenchymal stem cells (MSCs) are known to specifically migrate to and engraft at tumour sites. Understanding interactions between cancer cells and MSCs has become fundamental to determining whether ...
    • Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer 

      Hartmann, Marion C.; Dwyer, Róisín M.; Costello, M.; Potter, Shirley M.; Curran, Catherine E.; Hennessy, Emer; Newell, John; Griffin, Damian G.; Kerin, Michael J. (Elsevier, 2011-06-12)
      Purpose Investigate circulating CCL5 in breast cancer patients and healthy controls, along with gene expression levels in corresponding tumour tissue and isolated primary stromal cells. Hormonal control of CCL5, and a ...
    • Relationship between circulating and tissue microRNAs in a murine model of breast cancer. 

      Waters, Peadar S.; McDermott, Ailbhe M.; Wall, Deirdre; Heneghan, Helen M.; Miller, Nicola; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2012)
      MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...
    • Screening of exosomal microRNAs from colorectal cancer cells 

      Clancy, Cillian; Khan, Sonja; Glynn, Claire L.; Holian, Emma; Dockery, Peter; Lalor, Pierce; Brown, James A.L.; Joyce, Myles R.; Kerin, Michael J.; Dwyer, Róisín M. (IOS Press, 2017-01-03)
      BACKGROUND: Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown.OBJECTIVE: ...
    • The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue 

      Ryan, James; Curran, Catherine E.; Hennessy, Emer; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2011-01)
      Introduction: The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators ...
    • Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones 

      Potter, Shirley M.; Dwyer, Róisín M.; Curran, Catherine E.; Hennessy, Emer; Harrington, Kate A.; Griffin, Damian G.; Kerin, Michael J. (Springer, 2008-06-04)
      Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ...