Browsing Surgery (Scholarly Articles) by Title

Incidental findings on MRI scans of patients presenting with audiovestibular symptoms

Papanikolaou, Vasileios; Keogh, Ivan J. (Biomed Central, 2010)

Background:The evaluation of patients presenting with audiovestibular symptoms usually includes MRI of the internal auditory meatus, the cerebellopontine angle and the brain. A significant percentage of these scans will ...

Isolation of secreted microRNAs (miRNAs) from cell-conditioned media

Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)

MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ...

The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer

Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola (2012)

Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ...

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)

Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ...

MicroRNA expression in colorectal cancer.

Hogan, Niamh M.; Joyce, Myles R. (IOS Press, 2012-12-17)

Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ...

MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer

Chang, Kah Hoong; Mestdagh, Pieter; Vandesompele, Jo; Kerin, Michael J.; Miller, Nicola (Biomed Central, 2010)

Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ...

miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer

Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)

MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...

Modern management of pyogenic hepatic abscess: a case series and review of the literature

Heneghan, Helen M.; Healy, Nuala A. (BioMed Central, 2011-03)

Background Pyogenic hepatic abscesses are relatively rare, though untreated are uniformly fatal. A recent paradigm shift in the management of liver abscesses, facilitated by advances in diagnostic and interventional ...

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-04)

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ...