Now showing items 1-4 of 4

    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...
    • Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer 

      Hartmann, Marion C.; Dwyer, Róisín M.; Costello, M.; Potter, Shirley M.; Curran, Catherine E.; Hennessy, Emer; Newell, John; Griffin, Damian G.; Kerin, Michael J. (Elsevier, 2011-06-12)
      Purpose Investigate circulating CCL5 in breast cancer patients and healthy controls, along with gene expression levels in corresponding tumour tissue and isolated primary stromal cells. Hormonal control of CCL5, and a ...
    • Relationship between circulating and tissue microRNAs in a murine model of breast cancer. 

      Waters, Peadar S.; McDermott, Ailbhe M.; Wall, Deirdre; Heneghan, Helen M.; Miller, Nicola; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2012)
      MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...
    • The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue 

      Ryan, James; Curran, Catherine E.; Hennessy, Emer; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2011-01)
      Introduction: The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators ...