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Now showing items 1-13 of 13
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11q13 is a susceptibility locus for hormone receptor positive breast cancer.
Kerin, Michael J.; Miller, Nicola (Wiley, 2012-07)A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these ... -
Career choices of today's medical students: where does surgery rank?
Kerin, Michael J. (Springer, 2013-11-15)The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ... -
Clinical applications of gene expression in colorectal cancer.
Kerin, Michael J. (2013)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Endoscopic resection of nasopharyngeal angiofibroma: The role of radio-frequency coblation
Ali, Rohana; Keogh, Ivan; Lang, John (PagePress, 2011-08-29)Nasopharyngeal angiofibromas are histologically benign but locally aggressive vascular tumors that can result in major morbidity and mortality. They exclusively affect adolescent male and are rare in patients older than ... -
Enlarging neck masses in the elderly - Histological and surgical considerations.
O'Sullivan MD, McAnena KS, Egan C, Waters PS, McCann PJ, Kerin MJ (2013)INTRODUCTION: Anaplastic carcinoma of the thyroid is a rare but aggressive malignancy which can present with a rapidly enlarging neck mass or compressive sequelae of cough, dyspnoea, dysphagia and hoarseness. Treatment of ... -
Isolation of secreted microRNAs (miRNAs) from cell-conditioned media
Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ... -
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola (2012)Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ... -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ... -
MicroRNA expression in colorectal cancer.
Hogan, Niamh M.; Joyce, Myles R. (IOS Press, 2012-12-17)Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ... -
miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer
Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ... -
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-04)TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ... -
Preparing New Doctors for Clinical Practice: An Evaluation of Pre-Internship Training
Byrne, Dara; O'Connor, Paul; Lydon, Sinéad; Kerin, Michael J. (2012)A consistent finding in the literature is that newly graduated medical students often do not possess the basic skills required to perform their job. Training designed to prepare newly graduated medical students for internship ... -
Relationship between circulating and tissue microRNAs in a murine model of breast cancer.
Waters, Peadar S.; McDermott, Ailbhe M.; Wall, Deirdre; Heneghan, Helen M.; Miller, Nicola; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2012)MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...