Browsing School of Chemistry (Scholarly Articles) by Author "Gniado, Katarzyna"
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Application of ball milling for highly selective mechanochemical polymorph transformations
Kamali, Naghmeh; Gniado, Katarzyna; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2018-06-07)Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ... -
Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study
MacFhionnghaile, Pól; Hu, Yun; Gniado, Katarzyna; Curran, Sinead; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2014-04-11)The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete ... -
The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems
Gniado, Katarzyna; Löbmann, Korbinian; Rades, Thomas; Erxleben, Andrea (Elsevier, 2016-03-16)A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, ... -
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
Gniado, Katarzyna; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2018-10-28)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ...