Browsing School of Chemistry (Scholarly Articles) by Subject "Amorphous"
Now showing items 1-5 of 5
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Dual-drug amorphous formulation of gliclazide
(Taylor and Francis, 2021-02-01)Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ... -
Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study
(Elsevier, 2014-04-11)The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete ... -
Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug
(Elsevier, 2012-10-09)The formation and physical stability of amorphous sulfathiazole obtained from polymorphic forms I and III by cryomilling was investigated by X-ray powder diffraction (XRPD) and near-infrared (NIR) spectroscopy. Principal ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
(Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
(Elsevier, 2018-10-28)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ...