Browsing School of Chemistry (Scholarly Articles) by Author "http://dx.doi.org/10.13039/501100002081"
Now showing items 1-15 of 15
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Accurate anisotropy recovery from fluorophore mixtures using Multivariate Curve Resolution (MCR)
Casamayou-Boucau, Yannick; Ryder, Alan G. (Elsevier, 2017-11-22)Anisotropy resolved multidimensional emission spectroscopy (ARMES) provides valuable insights into multi-fluorophore systems like proteins that have complex overlapping emission bands. The method combines multidimensional ... -
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
Buckley, Kevin; Ryder, Alan G. (Sage Publications, 2017-05-23)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ... -
Design of experiments approach to provide enhanced glucose-oxidising enzyme electrode for membrane-less enzymatic fuel cells operating in human physiological fluids
Bennett, Richard; Osadebe, Isioma; Kumar, Rakesh; Ó Conghaile, Peter; Leech, Dónal (Wiley, 2018-03-30)Graphite electrodes are modified with a redox polymer, [Os(4,4-dimethoxy-2,2-bipyridine)(2)(polyvinylimidazole)(10)Cl](+) (E degrees=-0.02V vs Ag/AgCl (3M KCl), crosslinked with a flavin adenine dinucleotide glucose ... -
A detailed chemical kinetic modeling and experimental investigation of the low- and high-temperature chemistry of n-butylcyclohexane
Pitz, William J.; Liang, Jinhu; Kukkadapu, Goutham; Zhang, Kuiwen; Conroy, Christine; Bugler, John; Curran, Henry J. (Wiley, 2020-11-26)Chemical kinetic models of gasoline, jet, and diesel fuels and their mixtures with bioderived fuels are needed to assess fuel property effects on efficiency, emissions, and other performance metrics in internal combustion ... -
Development of Mcl-1 inhibitors for cancer therapy
Negi, Arvind; Murphy, Paul V. (Elsevier, 2020-11-24)The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a key role in survival of cancer ... -
Effect of individual plasma components on the performance of a glucose enzyme electrode based on redox polymer mediation of a flavin adenine dinucleotide-dependent glucose dehydrogenase
Bennett, Richard; Blochouse, Estelle; Leech, Dónal (Elsevier, 2019-02-11)The performance of glucose enzyme electrodes, consisting of crosslinked flavin adenine dinucleotide glucose dehydrogenase (FADGDH), an osmium redox polymer and multi-walled carbon nanotubes on graphite electrodes, was ... -
Electrochemical glucose biosensor based on an osmium redox polymer and glucose oxidase grafted to carbon nanotubes: A design-of-experiments optimisation of current density and stability
Jayakumar, Kavita; Bennett, Richard; Leech, Dónal (Elsevier, 2021-01-25)Enzymatic glucose electrodes based on mediated electron transfer have potential for application as semi-implantable or implantable sensors. Enzyme electrodes consisting of adsorbed osmium-based redox polymer crosslinked ... -
Extended wavelength anisotropy resolved multidimensional emission spectroscopy (ARMES) measurements: better filters, validation standards, and Rayleigh scatter removal methods
Casamayou-Boucau, Yannick; Ryder, Alan G. (IOP Publishing, 2017-08-17)Anisotropy resolved multidimensional emission spectroscopy (ARMES) provides valuable insights into multi-fluorophore proteins (Groza et al 2015 Anal. Chim. Acta 886 133-42). Fluorescence anisotropy adds to the multidimensional ... -
Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation
Farrell, Mark P.; Doyle, Lisa M.; Murphy, Paul V. (Elsevier, 2018-05-26)Lewis acid promoted anomerisation has potential in O- or S-glycoside synthesis. Herein, the anomerisation kinetics of thirty-one β-d-glucopyranosides was determined to determine how particular acyl protecting groups and ... -
Ligand design for somatostatin receptor isoforms 4 and 5
Negi, Arvind; Zhou, Jian; Sweeney, Sinclair; Murphy, Paul V. (Elsevier, 2018-11-17)The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ... -
N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
Zhou, Jian; Negi, Arvind; Mirallai, Styliana I.; Warta, Rolf; Herold-Mende, Christel; Carty, Michael P.; Ye, Xin-Shan; Murphy, Paul V. (Elsevier, 2018-12-04)1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the ¿-fucosidases of T. maritima (bacterial origin) ... -
Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes
Murphy, Paul V.; Romero, Antonio; Xiao, Qi; Ludwig, Anna-Kristin; Jogula, Srinivas; Shilova, Nadezhda V.; Singh, Tanuja; Gabba, Adele; Javed, Bilal; Zhang, Dapeng; Medrano, Francisco J.; Kaltner, Herbert; Kopitz, Jürgen; Bovin, Nicolai V.; Wu, Albert M.; Klein, Michael L.; Percec, Virgil; Gabius, Hans-Joachim (Cell Press, 2021-01-22)The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group ... -
Quantitative analysis of weakly bound insulin oligomers in solution using polarized multidimensional fluorescence spectroscopy
Casamayou-Boucau, Yannick; Ryder, Alan G. (Elsevier, 2020-09-08)Being able to measure the size and distribution of oligomers in solution is a critical issue in the manufacture and stability of insulin and other protein formulations. Measuring oligomers reliably can however be complicated, ... -
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V. (Royal Society of Chemistry, 2018-08-14)The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ... -
Super stable fluorescein isothiocyanate isomer I monolayer for total internal reflection fluorescence microscopy
Zarski, Przemyslaw; Ryder, Alan G. (American Chemical Society, 2018-08-27)Total internal reflection fluorescence microscopy (TIRFM) is an important method in surface science and for the analysis of surface-bound macromolecules. Here, we developed and explored the use of a novel fluorescein ...