Browsing School of Chemistry by Author "Tolan, Dina"
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Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid
Tolan, Dina; Almotairy, Awatif Rashed Z.; Howe, Orla; Devereux, Michael; Montagner, Diego; Erxleben, Andrea (Elsevier, 2019-04-19)The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(II) anticancer drugs allows the co-delivery and simultaneous activation of two pro-drugs for combination therapy. Pt(IV) ... -
Oxidative stress induced by Pt(IV) pro-drugs based on the cisplatin scaffold and indole carboxylic acids in axial position
Tolan, Dina; Gandin, Valentina; Morrison, Liam; El-Nahas, Ahmed; Marzano, Cristina; Montagner, Diego; Erxleben, Andrea (Nature Publishing Group, 2016-06-11)The use of Pt(IV) complexes as pro-drugs that are activated by intracellular reduction is a widely investigated approach to overcome the limitations of Pt(II) anticancer agents. A series of ten mono- and bis-carboxylated ...