Browsing School of Chemistry by Author "Manning, Joachim C."

Now showing items 1-3 of 3

    • Influence of protein (human galectin-3) design on aspects of lectin activity 

      Caballero, Gabriel Garcia; Beckwith, Donella; Shilova, Nadezhda, V.; Gabba, Adele; Kutzner, Tanja J.; Ludwig, Anna-Kristin; Manning, Joachim C.; Kaltner, Herbert; Sinowatz, Fred; Cudic, Mare; Bovin, Nicolai, V.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2020-04-25)
      The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge ...

    • Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform 

      Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V. (Royal Society of Chemistry, 2018-08-14)
      The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ...

    • Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design 

      Roy, René; Cao, Yihong; Kaltner, Herbert; Kottari, Naresh; Shiao, Tze Chieh; Belkhadem, Karima; André, Sabine; Manning, Joachim C.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2016-06-24)
      A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...