Now showing items 1-4 of 4

    • Cocrystal forms of the BCS class IV drug sulfamethoxazole 

      Alsubaie, Moneerh; Aljohani, Marwah; Erxleben, Andrea; McArdle, Patrick (American Chemical Society, 2018-05-23)
      Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve ...
    • A comprehensive cocrystal screening study of chlorothiazide 

      Aljohani, Marwah; Pallipurath, Anuradha R.; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2017-09-01)
      Cocrystal formation of chlorothiazide (ctz) was screened with a variety of coformers with carboxyl, amide, hydroxyl, sulfonamide, pyridine, amidine, and amine functional groups. New cocrystals with acetamide (aca), benzamide ...
    • Hydrogen bonding networks and solid-state conversions in benzamidinium salts 

      Kamali, Naghmeh; Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (2015-07-14)
      Ten benzamidinium salts of carboxylic acids, amides, and sulfonamides have been crystallized from solution. Single-crystal X-ray analyses revealed various hydrogen bonding motifs which ate discussed in terms of supramolecular ...
    • Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide 

      Aljohani, Marwah; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2019-02-23)
      The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ...