Browsing School of Chemistry by Title
Now showing items 19-38 of 360
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Analyzing protein conjugation reactions for antibody-drug conjugate synthesis using polarized excitation emission matrix spectroscopy
(Wiley, 2022-09-07)Antibody-drug conjugates (ADCs) are promising anticancer therapeutics, which offer important advantages compared to more classical therapies. There are a variety of ADC critical quality attributes (CQAs) such as the protein ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES): A new tool for protein analysis
(Elsevier, 2015-07-30)Structural analysis of proteins using the emission of intrinsic fluorophores is complicated by spectral overlap. Anisotropy resolved multidimensional emission spectroscopy (ARMES) overcame the overlap problem by the use ... -
Anomer preferences for glucuronic and galacturonic acid and derivatives and influence of electron-withdrawing substituents
(American Chemical Society, 2018-07-04)Equilibrium anomeric ratios are reported for pyranoses (hemiacetals) of glucuronic and galacturonic acid and their derivatives. These are compared to related gluco- and galactopyranoses and to deoxyfluorogluco- and ... -
Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid
(Elsevier, 2017-09-10)Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by 1H and 195Pt NMR spectroscopy, electrospray ... -
Application of ball milling for highly selective mechanochemical polymorph transformations
(American Chemical Society, 2018-06-07)Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ... -
Application of vibrational spectroscopy to study solid-state transformations of pharmaceuticals
(2016-09-01)Understanding the properties, stability and transformations of the solid-state forms of an active pharmaceutical ingredient (API) in the development pipeline is of crucial importance for process-development, formulation ... -
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
(Sage Publications, 2017-05-23)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ... -
Assessing the predictions of a NOx kinetic mechanism on recent hydrogen and syngas experimental data
(Elsevier, 2017-05-02)A detailed chemical kinetic mechanism has been developed to describe the pyrolysis and oxidation of the hydrogen/NOx and syngas/NOx systems. The thermodynamic data of nitrogenous compounds have been updated based on the ... -
Atomistic study of zwitterionic peptoid antifouling brushes
(NUI Galway, 2018-09-03)Simulation files, analysis scripts, and output data to accompany article: Cheung, David L., & Lau, King Hang Aaron. (2018). Atomistic Study of Zwitterionic Peptoid Antifouling Brushes. Langmuir. doi: 10.1021/acs.langm ... -
Atomistic study of zwitterionic peptoid antifouling brushes
(American Chemical Society, 2018-08-24)Using molecular dynamics (MD) simulations, we study the molecular behavior and hydration properties of a set of zwitterionic peptoid brushes, grafted on a rutile surface, that has been previously reported to exhibit ... -
Autoignition characteristics of oxygenated gasolines
(Elsevier, 2017-08-14)Gasoline anti-knock quality, defined by the research and motor octane numbers (RON and MON), is important for increasing spark ignition (SI) engine efficiency. Gasoline knock resistance can be increased using a number of ... -
Autoignition of ethanol in a rapid compression machine
(Elsevier, 2013-12-09)Ethanol is a renewable source of energy and significant attention has been directed to the development of a validated chemical kinetic mechanism for this fuel. The experimental data for the autoignition of ethanol in the ... -
Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
(Royal Society of Chemistry, 2015-02-17)Emerging insights into the functional spectrum of tissue lectins leads to identification of new targets for the custom-made design of potent inhibitors, providing a challenge for synthetic chemistry. The affinity and ... -
Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity.
(Royal Society of Chemistry, 2012-06-29)The emerging functional versatility of cellular glycans makes research on the design of synthetic inhibitors a timely topic. In detail, the combination of ligand (or headgroup or contact site) structure with spatial ... -
Bioelectrochemical Haber-Bosch process: An ammonia-producing H-2/N-2 fuel cell
(Wiley, 2017-02-03)Nitrogenases are the only enzymes known to reduce molecular nitrogen (N-2) to ammonia (NH3). By using methyl viologen (N, N'-dimethyl-4,4'-bipyridinium) to shuttle electrons to nitrogenase, N-2 reduction to NH3 can be ... -
Bodipy-ruthenium(II) tris-bipyridyl dyads for homogeneous photochemical oxidations
(Elsevier, 2014-10-28)Two Bodipy-ruthenium(II) tris-bipyridyl dyads were synthesized for use as sensitizers in photochemical oxidation reactions of organic substrates. The synthetic strategy involved the use of a simple ‘click’ CuAAC reaction ... -
A Bpp-based dinuclear ruthenium photocatalyst for visible light-driven oxidation reactions
(Royal Society of Chemistry, 2019-11-05)A diruthenium dyad molecule consisting of a 2,2-(1H-pyrazole-3,5-diyl)dipyridine (Hbpp) bridging ligand with the formula out-/in-[(bpy)2Ru(bpp)Ru(L)(tpy)]n+ (bpy = 2,2′-bipyridine, tpy = 2,2′:6′,2′′-terpyridine, L = Cl, ... -
Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis
(Elsevier, 2020-09-18)Synthesis of compounds with characteristics of natural products are required to increase the diversity and biological relevance of compounds for screening. These include new frameworks/scaffolds, with multiple stereogenic ... -
Calibration, standardization, and quantitative analysis of multidimensional fluorescence (MDF) measurements on complex mixtures (IUPAC Technical Report)
(De Gruyter, 2017-11-15)This IUPAC Technical Report describes and compares the currently applied methods for the calibration and standardization of multi-dimensional fluorescence (MDF) spectroscopy data as well as recommendations on the correct ... -
Calixarene-mediated assembly of a small antifungal protein
(International Union of Crystallography, 2019-02-05)Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more ...