Show simple item record

Ghrelin in the human myometrium

dc.contributor.authorO'Brien, Margareten
dc.contributor.authorEarley, Padraigen
dc.contributor.authorMorrison, John J.en
dc.contributor.authorSmith, Terryen
dc.date.accessioned2010-05-31T11:17:39Zen
dc.date.available2010-05-31T11:17:39Zen
dc.date.issued2010-03-29en
dc.identifier.citationO'Brien, M., Earley, P., Morrison, J., & Smith, T. (2010). Ghrelin in the human myometrium. Reproductive Biology and Endocrinology, 8(1), 55.en
dc.identifier.urihttp://hdl.handle.net/10379/1133en
dc.description.abstractGhrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human contractility in vitro. The aim of this study therefore, was to investigate the expression of ghrelin, its receptor, the growth hormone secretagogue receptor type 1 (GHS-R1), ghrelin O-acyltransferase (GOAT) which catalyses ghrelin octanoylation, prohormone convertase 1/3 (PC1/3) responsible for pro-ghrelin processing, in human myometrium, during pregnancy prior to labour, during labour and in the non-pregnant state. Modulation of ghrelin and ghrelin receptor expression in cultured myometrial cells was also investigated.en
dc.description.sponsorshipHealth Research Board of Ireland and the Higher Education Authority of Ireland (Program for Research in Third Level Institutions).en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherBioMed Central Ltden
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectGhrelinen
dc.subjectGrowth hormone releaseen
dc.subjectNCBESen
dc.titleGhrelin in the human myometriumen
dc.typeArticleen
dc.identifier.doidoi:10.1186/1477-7827-8-55en
dc.local.publishedsourcehttp://www.rbej.com/content/8/1/55en
dc.description.peer-reviewedpeer-revieweden
nui.item.downloads573


Files in this item

Thumbnail
Name:
license.txt
Size:
5.659Kb
Format:
Text file
View/Open
Thumbnail
Name:
Ghrelin in the human myometrium.pdf
Size:
1.149Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland