Browsing by Subject "s-phase checkpoint"
Now showing items 1-3 of 3
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C-jun n-terminal kinase-mediated rad18 phosphorylation facilitates pol recruitment to stalled replication forks
(American Society for Cell Biology (ASCB), 2012-03-28)The E3 ubiquitin ligase Rad18 chaperones DNA polymerase eta (Pol eta) to sites of UV-induced DNA damage and monoubiquitinates proliferating cell nuclear antigen (PCNA), facilitating engagement of Pol eta with stalled ... -
Mrc1, tof1 and csm3 inhibit cag·ctg repeat instability by at least two mechanisms
(Elsevier BV, 2008-04-01)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion rates. ... -
The mrn complex: coordinating and mediating the response to broken chromosomes
(Wiley-Blackwell, 2003-09-01)The MRE11-RAD50-NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double-stranded breaks (DSBs). In vertebrate cells, all three components are encoded by essential genes, and hypomorphic ...