Browsing by Author "Wall, J. Gerard"
Now showing items 1-5 of 5
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Development of a targeting mechanism for regeneration of the intervertebral disc
Cunningham, Claire (2014-11-24)Degeneration of the intervertebral discs (IVD) is a leading cause of neck and low back pain. While its aetiology is poorly understood, it is known to begin in the central nucleus pulposus region, leading to degradation of ... -
Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase xii varies with age and degeneration
Power, Karen A.; Grad, Sibylle; Rutges, Joost P. H. J.; Creemers, Laura B.; van Rijen, Mattie H. P.; O'Gaora, Peadar; Wall, J. Gerard; Alini, Mauro; Pandit, Abhay; Gallagher, William M. (Wiley-Blackwell, 2011-11-29)Objective Back pain is a major cause of disability, affecting millions of people worldwide. One cause of axial back pain is degeneration of the nucleus pulposus (NP) of the intervertebral disc. This study was undertaken ... -
Isolation and characterisation of a recombinant antibody fragment that binds ncam1-expressing intervertebral disc cells
Cunningham, Claire; Srivastava, Akshay; Collin, Estelle; Grad, Sibylle; Alini, Mauro; Pandit, Abhay; Wall, J. Gerard (Public Library of Science (PLoS), 2013-12-13)Degeneration of the intervertebral discs (IVD) is a leading cause of neck and low back pain. Degeneration begins in the central nucleus pulposus region, leading to loss of IVD osmotic properties. Regeneration approaches ... -
Thermal unfolding and refolding of lysozyme in deep eutectic solvents and their aqueous dilutions
Esquembre, Rocio; Sanz, Jesus M.; Wall, J. Gerard; del Monte, Francisco; Mateo, C. Reyes; Ferrer, M. Luisa (Royal Society of Chemistry (RSC), 2013-01-01)The stability of hen's egg white lysozyme in different choline chloride-based pseudo-concentrated and neat deep eutectic solvents (DESs) has been studied by means of intrinsic fluorescence and CD spectroscopy. Thermal ... -
Trigger Factor from the Psychrophilic Bacterium Psychrobacter frigidicola Is a Monomeric Chaperone
Robin, Sylvain; Togashi, Denisio M.; Ryder, Alan G.; Wall, J. Gerard (American Society for Microbiology, 2009)In eubacteria, trigger factor (TF) is the first chaperone to interact with newly synthesized polypeptides and assist their folding as they emerge from the ribosome. We report the first characterization of a TF from a ...